FB2024_03 , released June 25, 2024
Experimental tool: Tag:CAAX(hKRAS)
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General Information
Symbol
Tag:CAAX(hKRAS)
FlyBase ID
FBto0000195
Name
Endomembrane targeting sequence
Description
Description

Tag:CAAX(hKRAS) represents a CAAX prenylation motif (CVIM) derived from the 4B isoform of the Homo sapiens KRAS gene (HGNC:6407), where the polybasic domain normally found associated with this motif in KRAS is either not present or has been mutated to contain non-charged amino acids. When fused to the C-terminal end of a protein of interest, Tag:CAAX(hKRAS) results in the tagged protein being targeted to the endomembrane system (PMID:10412982, FBrf0212407).

Uses
External Crossreferences and Linkouts
Related experimental tools
Transgenic Constructs
Insertions ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Ktail6Q
(FlyBase, 1992-)
T:Hsap\CAAX6Q
(FlyBase, 1992-)
Tag:CAAX(hKRAS)
Name Synonyms
Endomembrane targeting sequence
Secondary FlyBase IDs
  • FBal0248801
References (8)