FB2024_03 , released June 25, 2024
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Marin, E.C., Büld, L., Theiss, M., Sarkissian, T., Roberts, R.J.V., Turnbull, R., Tamimi, I.F.M., Pleijzier, M.W., Laursen, W.J., Drummond, N., Schlegel, P., Bates, A.S., Li, F., Landgraf, M., Costa, M., Bock, D.D., Garrity, P.A., Jefferis, G.S.X.E. (2020). Connectomics Analysis Reveals First-, Second-, and Third-Order Thermosensory and Hygrosensory Neurons in the Adult Drosophila Brain.  Curr. Biol. 30(16): 3167--3182.e4.
FlyBase ID
FBrf0246456
Publication Type
Research paper
Abstract
Animals exhibit innate and learned preferences for temperature and humidity-conditions critical for their survival and reproduction. Leveraging a whole-brain electron microscopy volume, we studied the adult Drosophila melanogaster circuitry associated with antennal thermo- and hygrosensory neurons. We have identified two new target glomeruli in the antennal lobe, in addition to the five known ones, and the ventroposterior projection neurons (VP PNs) that relay thermo- and hygrosensory information to higher brain centers, including the mushroom body and lateral horn, seats of learned and innate behavior. We present the first connectome of a thermo- and hygrosensory neuropil, the lateral accessory calyx (lACA), by reconstructing neurons downstream of heating- and cooling-responsive VP PNs. A few mushroom body-intrinsic neurons solely receive thermosensory input from the lACA, while most receive additional olfactory and thermo- and/or hygrosensory PN inputs. Furthermore, several classes of lACA-associated neurons form a local network with outputs to other brain neuropils, suggesting that the lACA serves as a hub for thermo- and hygrosensory circuitry. For example, DN1a neurons link thermosensory PNs in the lACA to the circadian clock via the accessory medulla. Finally, we survey strongly connected downstream partners of VP PNs across the protocerebrum; these include a descending neuron targeted by dry-responsive VP PNs, meaning that just two synapses might separate hygrosensory inputs from motor circuits. These data provide a comprehensive first- and second-order layer analysis of Drosophila thermo- and hygrosensory systems and an initial survey of third-order neurons that could directly modulate behavior.
PubMed ID
PubMed Central ID
PMC7443704 (PMC) (EuropePMC)
Related Publication(s)
Note

Connectomics: Bringing Fly Neural Circuits into Focus.
Lizbinski and Jeanne, 2020, Curr. Biol. 30(16): R944--RR947 [FBrf0246535]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Biol.
    Title
    Current Biology
    Publication Year
    1991-
    ISBN/ISSN
    0960-9822
    Data From Reference