Vorobyeva, N.E., Nikolenko, J.V., Krasnov, A.N., Kuzmina, J.L., Panov, V.V., Nabirochkina, E.N., Georgieva, S.G., Shidlovskii, Y.V. (2011). SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation.  Cell Cycle 10(11): 1821--1827.

FBrf0213948

Research paper

The role of metazoan coactivator SAYP in nuclear receptor-driven gene activation in the ecdysone cascade of Drosophila is considered. SAYP interacts with DHR3 nuclear receptor and activates the corresponding genes by recruiting the BTFly (Brahma and TFIID) coactivator supercomplex. The knockdown of SAYP leads to a decrease in the level of DHR3-activated transcription. DHR3 and SAYP interact during development and have multiple common targets across the genome.