Tei, H., Nihonmatsu, I., Yokokura, T., Ueda, R., Sano, Y., Okuda, T., Sato, K., Hirata, K., Fujita, S.C., Yamamoto, D. (1992). pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor.  Proc. Natl. Acad. Sci. U.S.A. 89(): 6856--6860.

FBrf0057549

Research paper

Studies on sevenless and bride of sevenless genes have revealed that the R8 cell plays a key role in the fate of the R7 photoreceptor cell, presenting on its surface an inductive cue to which R7 responds. sev-independent induction of R7 cells has been reported in the seven-up mutation, which appears to transform R1 and R6 cells to R7 cells. We have induced recessive mutations in a gene pokkuri (pok; pokkuri is a Japanese word that means "dropping dead") that lead to overproduction of R7 cells with rather minor effects on outer photoreceptors and R8 cells. Pok protein may function as a transcription factor, as the predicted amino acid sequence contains a region similar to the consensus established for the E-26-specific (Ets) domain.

PMC49603 (PMC) (EuropePMC)