FB2024_04 , released June 25, 2024
Gene: Dmel\vis
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General Information
Symbol
Dmel\vis
Species
D. melanogaster
Name
vismay
Annotation Symbol
CG8821
Feature Type
protein_coding_gene
FlyBase ID
FBgn0033748
Gene Model Status
Current
Stock Availability
10 publicly available
Gene Summary
vismay (vis) encodes a transcription factor that contributes to spermatogenesis. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)
All Summaries
Also Known As

zaa, achi/vis

Key Links
Genomic Location
Cytogenetic map
49A10-49A10
Sequence location
Recombination map
2-67
RefSeq locus
NT_033778 REGION:12507896..12510615
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables DNA-binding transcription activator activity, RNA polymerase II-specific
inferred from direct assay
(Hyman et al., 2003)
enables protein binding
inferred from physical interaction with FLYBASE:Mad; FB:FBgn0011648
(Hyman et al., 2003)
inferred from physical interaction with FLYBASE:Smox; FB:FBgn0025800
(Hyman et al., 2003)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA binding
inferred from electronic annotation with InterPro:IPR001356, InterPro:IPR008422
(InterPro Project Members, 2004-)
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN001723890
(GO Reference Genome Project, 2011-)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN001723890
(GO Reference Genome Project, 2011-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in positive regulation of DNA-templated transcription
inferred from direct assay
(Hyman et al., 2003)
involved_in spermatogenesis
inferred from expression pattern
(Ayyar et al., 2003, Wang and Mann, 2003)
inferred from mutant phenotype
(Ayyar et al., 2003, Wang and Mann, 2003)
inferred from physical interaction with FLYBASE:aly; FB:FBgn0004372
(Wang and Mann, 2003)
inferred from physical interaction with FLYBASE:comr; FB:FBgn0034667
(Wang and Mann, 2003)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in regulation of DNA-templated transcription
inferred from electronic annotation with InterPro:IPR008422
(InterPro Project Members, 2004-)
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN001723890
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Hyman et al., 2003)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001723890
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
vismay (vis) encodes a transcription factor that contributes to spermatogenesis. [Date last reviewed: 2019-09-12]
Gene Group (FlyBase)
TALE HOMEOBOX TRANSCRIPTION FACTORS -
TALE homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. These proteins are characterized by an atypical homeodomain that possesses a three amino acid insertion in the first loop. (Adapted from FBrf0232555 and PMID:18797923).
Summary (Interactive Fly)

homeodomain transcription factor (TGIF subclass) - required, along with homeodomain protein Vismay, for for meiotic division in spermatogenesis

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\vis for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A1Z913)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.49

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
vis-RA
FBtr0087944
NM_078990
1741
424
vis-RB
FBtr0087945
NM_176157
2124
524
Additional Transcript Data and Comments
Reported size (kB)

1.6, 1.2 (northern blot)

(Ayyar et al., 2003)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
vis-PA
FBpp0087055
47.2
424
4.47
Q7K380
NP_523714
AAG22280
vis-PB
FBpp0087056
58.3
524
4.83
A1Z913
NP_788337
AAO41402
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

80, 60 (kD)

(Wang and Mann, 2003)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\vis using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

3.12

Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
testis

Comment: RA and RB transcripts

(Ayyar et al., 2003)
adult stage | female
organism

Comment: RA transcript only

(Ayyar et al., 2003)
adult stage | male
organism

Comment: gonadectomized bodies; RA transcript only

(Ayyar et al., 2003)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
organism
(Ayyar et al., 2003)
adult stage
testis | restricted
(Ayyar et al., 2003)
testis

Comment: RA and RB transcripts

(Ayyar et al., 2003)
adult stage | female
organism

Comment: RA transcript only

(Ayyar et al., 2003)
adult stage | male
organism

Comment: gonadectomized bodies; RA transcript only

(Ayyar et al., 2003)
Additional Descriptive Data

Developmental RT PCR analysis using a probe that detects all isoforms of both achi and vis indicate roughly equal expression through all stages of development. In situ analysis of adult testes detect high achi and/or vis expression in the primary spermatocyte stage, persisting into the meiotic divisions. No expression is detect in the apex.

(Ayyar et al., 2003)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism
• nucleus
(Wang and Mann, 2003)
larval stage
wing disc
• nucleus
(Wang and Mann, 2003)
adult stage | male
spermatocyte

Comment: meiotic metaphase

(Wang and Mann, 2003)
spermatocyte
• nucleus

Comment: NOT meiotic metaphase

(Wang and Mann, 2003)
adult stage
spermatid

Comment: NOT mitochondrion

(Wang and Mann, 2003)
egg chamber
• nucleus
(Wang and Mann, 2003)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
ovary
(Wang and Mann, 2003)
organism
(Wang and Mann, 2003)
testis
(Wang and Mann, 2003)
Additional Descriptive Data

The smaller isoformof both achi and vis is found in both males and females and in males is expressed in both the testis and somatic tissue.

(Wang and Mann, 2003)

The long isoform ofboth achi and vis is testis specific.

(Wang and Mann, 2003)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Hyman et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\vis in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of vis
Transgenic constructs containing regulatory region of vis
Aberrations (Deficiencies and Duplications) ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (25)
Hsap\TGIF2
8 of 14
Yes
Yes
2  
Hsap\TGIF1
7 of 14
No
Yes
Hsap\TGIF2LX
4 of 14
No
Yes
1  
Hsap\TGIF2LY
4 of 14
No
Yes
1  
Hsap\MEIS2
3 of 14
No
No
1  
Hsap\MEIS3
3 of 14
No
No
Hsap\PKNOX1
3 of 14
No
No
1  
Hsap\PKNOX2
3 of 14
No
No
Hsap\IRX1
2 of 14
No
No
Hsap\IRX6
2 of 14
No
No
Hsap\MEIS1
2 of 14
No
No
Hsap\PBX1
2 of 14
No
No
Hsap\PBX4
2 of 14
No
No
1  
Hsap\CUX2
1 of 14
No
No
Hsap\IRX2
1 of 14
No
No
Hsap\IRX3
1 of 14
No
No
Hsap\IRX4
1 of 14
No
No
Hsap\IRX5
1 of 14
No
No
Hsap\MEIS3P1
1 of 14
No
No
Hsap\MEIS3P2
1 of 14
No
No
Hsap\MKX
1 of 14
No
No
Hsap\PBX2
1 of 14
No
No
Hsap\PBX3
1 of 14
No
No
Hsap\SIX1
1 of 14
No
No
Hsap\TGIF2-RAB5IF
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (19)
Rnor\Tgif1
8 of 14
Yes
Yes
Rnor\Tgif2
8 of 14
Yes
Yes
Rnor\Meis2
3 of 14
No
No
Rnor\Meis3
3 of 14
No
No
Rnor\Pknox1
3 of 14
No
No
Rnor\Pknox2
3 of 14
No
No
Rnor\Irx1
2 of 14
No
No
Rnor\Irx6
2 of 14
No
No
Rnor\Meis1
2 of 14
No
No
Rnor\Pbx2
2 of 14
No
No
Rnor\Pbx4
2 of 14
No
No
Rnor\Tgif2lx2
2 of 14
No
Yes
Rnor\Cux2
1 of 14
No
No
Rnor\Irx4
1 of 14
No
No
Rnor\Irx5
1 of 14
No
No
Rnor\Mkx
1 of 14
No
No
Rnor\Pbx1
1 of 14
No
No
Rnor\Pbx3
1 of 14
No
No
Rnor\Six1
1 of 14
No
No
Mus musculus (laboratory mouse) (22)
Mmus\Tgif1
8 of 14
Yes
Yes
Mmus\Tgif2
7 of 14
No
Yes
Mmus\Tgif2lx1
4 of 14
No
Yes
Mmus\Tgif2lx2
4 of 14
No
Yes
Mmus\Meis2
3 of 14
No
No
Mmus\Meis3
3 of 14
No
No
Mmus\Pknox1
3 of 14
No
No
Mmus\Pknox2
3 of 14
No
No
Mmus\Irx1
2 of 14
No
No
Mmus\Irx6
2 of 14
No
No
Mmus\Meis1
2 of 14
No
No
Mmus\Pbx1
2 of 14
No
No
Mmus\Pbx2
2 of 14
No
No
Mmus\Pbx4
2 of 14
No
No
Mmus\Cux2
1 of 14
No
No
Mmus\Irx2
1 of 14
No
No
Mmus\Irx3
1 of 14
No
No
Mmus\Irx4
1 of 14
No
No
Mmus\Irx5
1 of 14
No
No
Mmus\Mkx
1 of 14
No
No
Mmus\Pbx3
1 of 14
No
No
Mmus\Six1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (17)
Xtro\tgif2
5 of 13
Yes
No
Xtro\tgif1
4 of 13
No
Yes
Xtro\arl15
1 of 13
No
Yes
Xtro\b3galt5.1
1 of 13
No
No
Xtro\elp2
1 of 13
No
No
Xtro\hoxa3
1 of 13
No
No
Xtro\irx1
1 of 13
No
No
Xtro\meis3
1 of 13
No
No
Xtro\nipa1
1 of 13
No
Yes
Xtro\nkx6-1
1 of 13
No
Yes
Xtro\nyap2
1 of 13
No
No
Xtro\pbx1
1 of 13
No
No
Xtro\pbx2
1 of 13
No
No
Xtro\pknox2
1 of 13
No
No
Xtro\rab8b
1 of 13
No
No
Xtro\riox1
1 of 13
No
No
Xtro\ubr7
1 of 13
No
No
Danio rerio (Zebrafish) (28)
Drer\tgif1
8 of 14
Yes
Yes
Drer\LOC100535338
6 of 14
No
Yes
Drer\meis1a
3 of 14
No
No
Drer\meis1b
3 of 14
No
No
Drer\pknox1.1
3 of 14
No
No
Drer\pknox1.2
3 of 14
No
No
Drer\pknox2
3 of 14
No
No
Drer\irx3b
2 of 14
No
No
Drer\meis2a
2 of 14
No
No
Drer\meis2b
2 of 14
No
No
Drer\meis3
2 of 14
No
No
Drer\pbx1a
2 of 14
No
No
Drer\pbx1b
2 of 14
No
No
Drer\pbx4
2 of 14
No
No
Drer\hoxb10a
1 of 14
No
No
Drer\irx1b
1 of 14
No
No
Drer\irx2a
1 of 14
No
No
Drer\irx4a
1 of 14
No
No
Drer\irx4b
1 of 14
No
No
Drer\irx5a
1 of 14
No
No
Drer\irx5b
1 of 14
No
No
Drer\irx6a
1 of 14
No
No
Drer\irx7
1 of 14
No
No
Drer\mkxa
1 of 14
No
No
Drer\pbx2
1 of 14
No
No
Drer\pbx3a
1 of 14
No
No
Drer\pbx3b
1 of 14
No
No
Drer\six1a
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\ceh-60
2 of 14
Yes
No
Cele\ceh-20
1 of 14
No
No
Cele\eyg-1
1 of 14
No
No
Cele\irx-1
1 of 14
No
No
Cele\unc-62
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (7)
Agam\AgaP_AGAP007018
9 of 12
Yes
Yes
Agam\AgaP_AGAP002178
2 of 12
No
No
Agam\AgaP_AGAP007539
2 of 12
No
No
Agam\AgaP_AGAP005010
1 of 12
No
No
Agam\AgaP_AGAP005011
1 of 12
No
No
Agam\AgaP_AGAP009986
1 of 12
No
No
Agam\EXD_ANOGA
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (21)
Atha\BLH3
2 of 13
Yes
No
Atha\BLH5
2 of 13
Yes
No
Atha\BLH6
2 of 13
Yes
No
Atha\BLH7
2 of 13
Yes
No
Atha\BLH8
2 of 13
Yes
No
Atha\BLH11
2 of 13
Yes
No
Atha\RPL
2 of 13
Yes
No
Atha\ATH1
1 of 13
No
No
Atha\BEL1
1 of 13
No
No
Atha\BEL10
1 of 13
No
No
Atha\BLH1
1 of 13
No
No
Atha\BLH2
1 of 13
No
No
Atha\BLH4
1 of 13
No
No
Atha\KNAT1
1 of 13
No
No
Atha\KNAT2
1 of 13
No
No
Atha\KNAT3
1 of 13
No
No
Atha\KNAT4
1 of 13
No
No
Atha\KNAT5
1 of 13
No
No
Atha\KNAT6
1 of 13
No
No
Atha\KNAT7
1 of 13
No
No
Atha\STM
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\CUP9
3 of 13
Yes
No
Scer\TOS8
2 of 13
No
No
Scer\HMLALPHA2
1 of 13
No
No
Scer\HMRA2
1 of 13
No
No
Scer\MATALPHA2
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:vis. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (7)
achi
10 of 13
hth
4 of 13
exd
2 of 13
ara
1 of 13
caup
1 of 13
CG11617
1 of 13
mirr
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    TGIF1; TGFB induced factor homeobox 1
    model of  holoprosencephaly 4
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    visHMS01480
    exacerbates  atypical teratoid rhabdoid tumor
    modeled by Snr1KK101602
    (Tegeder et al., 2019)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TGIF2; TGFB induced factor homeobox 2
    8 of 14
    607294
         
        TGIF1; TGFB induced factor homeobox 1
        7 of 14
        602630
        TGIF2LX; TGFB induced factor homeobox 2 like X-linked
        4 of 14
        300411
             
            TGIF2LY; TGFB induced factor homeobox 2 like Y-linked
            4 of 14
            400025
                 
                MEIS2; Meis homeobox 2
                3 of 14
                601740
                 
                MEIS3; Meis homeobox 3
                3 of 14
                619443
                    PKNOX1; PBX/knotted 1 homeobox 1
                    3 of 14
                    602100
                         
                        PKNOX2; PBX/knotted 1 homeobox 2
                        3 of 14
                        613066
                            Functional Complementation Data
                            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                            Interactions
                            Summary of Physical Interactions
                            esyN Network Diagram
                            Show neighbor-neighbor interactions:
                            Show/hide secondary interactors 
                            (data from AllianceMine provided by esyN)
                            Select Layout:
                            Legend:
                            Protein
                            RNA
                            Selected Interactor(s)
                            Other Interaction Browsers
                            View in FlyBase Interactions Browser   View in MIST tool (external link)
                            Please see the Physical Interaction reports below for full details
                            protein-protein
                            Physical Interaction
                            Assay
                            References
                            vis - CG10669
                            two hybrid array
                            (Shokri et al., 2019)
                            vis - CG14667
                            two hybrid array
                            (Shokri et al., 2019)
                            vis - CG15445
                            two hybrid, experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting
                            (Hu et al., 2017.6.13, Rhee et al., 2014, Guruharsha et al., 2011)
                            vis - CG17272
                            anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
                            (Rhee et al., 2014)
                            vis - CG31642
                            two hybrid array
                            (Shokri et al., 2019)
                            vis - CG34179
                            anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
                            (Rhee et al., 2014)
                            vis - CG3726
                            two hybrid array
                            (Shokri et al., 2019)
                            vis - CG4424
                            two hybrid array
                            (Shokri et al., 2019)
                            vis - Kdm5
                            two hybrid array
                            (Shokri et al., 2019)
                            vis - Mad
                            anti tag coimmunoprecipitation, anti tag western blot
                            (Hyman et al., 2003)
                            vis - Mnt
                            two hybrid array
                            (Shokri et al., 2019)
                            vis - NFAT
                            two hybrid array
                            (Shokri et al., 2019)
                            vis - Nup35
                            anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
                            (Rhee et al., 2014)
                            vis - Pph13
                            two hybrid array
                            (Shokri et al., 2019)
                            vis - Smox
                            anti tag coimmunoprecipitation, anti tag western blot
                            (Hyman et al., 2003)
                            vis - achi
                            anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
                            (Rhee et al., 2014, Guruharsha et al., 2011)
                            vis - grh
                            two hybrid array
                            (Shokri et al., 2019)
                            vis - sens-2
                            two hybrid array
                            (Shokri et al., 2019)
                            Summary of Genetic Interactions
                            esyN Network Diagram
                            Show/hide secondary interactors 
                            (data from AllianceMine provided by esyN)
                            esyN Network Key:
                            Suppression
                            Enhancement
                            Other Interaction Browsers
                            View in FlyBase Interactions Browser   View in MIST tool (external link)
                            Please look at the allele data for full details of the genetic interactions
                            Starting gene(s)
                            Interaction type
                            Interacting gene(s)
                            Reference
                            Starting gene(s)
                            Interaction type
                            Interacting gene(s)
                            Reference
                            brm
                            suppressible
                            vis
                            (Tegeder et al., 2019)
                            Snr1
                            suppressible
                            vis
                            (Tegeder et al., 2019)
                            External Data
                            Linkouts
                            DroID - A comprehensive database of gene and protein interactions.
                            MIST (protein-protein) - An integrated Molecular Interaction Database
                            Pathways
                            Signaling Pathways (FlyBase)
                            Metabolic Pathways
                            External Data
                            Linkouts
                            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                            Genomic Location and Detailed Mapping Data
                            Chromosome (arm)
                            2R
                            Recombination map
                            2-67
                            Cytogenetic map
                            49A10-49A10
                            Sequence location
                            FlyBase Computed Cytological Location
                            Cytogenetic map
                            Evidence for location
                            49A10-49A10
                            Limits computationally determined from genome sequence between P{lacW}fdlk17040 and P{EP}CG8569EP1182
                            Experimentally Determined Cytological Location
                            Cytogenetic map
                            Notes
                            References
                            Experimentally Determined Recombination Data
                            Location

                            2-67

                            (FlyBase, 2016)

                            2-68.6

                            (Comeron et al., 2012)

                            2-65.5 +/- 3.3

                            (White-Cooper, 1999.3.3)
                            Left of (cM)
                            (White-Cooper, 1999.3.3)
                            Right of (cM)
                            (White-Cooper, 1999.3.3)
                            Notes
                            Stocks and Reagents
                            Stocks (10)
                            Genomic Clones (29)
                            cDNA Clones (5)
                             

                            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                            cDNA clones, fully sequenced
                            BDGP DGC clones
                              Other clones
                                Drosophila Genomics Resource Center cDNA clones

                                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                cDNA Clones, End Sequenced (ESTs)
                                BDGP DGC clones
                                  Other clones
                                    RNAi and Array Information
                                    Linkouts
                                    DRSC - Results frm RNAi screens
                                    Antibody Information
                                    Laboratory Generated Antibodies
                                     

                                    polyclonal

                                    (Wang and Mann, 2003)
                                    Commercially Available Antibodies
                                     
                                    Cell Line Information
                                    Publicly Available Cell Lines
                                     
                                      Other Stable Cell Lines
                                       
                                        Other Comments

                                        achi and vis are essential for developmentally regulated transcription during spermatogenesis.

                                        (Ayyar et al., 2003)

                                        achi, vis, aly and comr proteins may exist in a complex.

                                        (Wang and Mann, 2003)

                                        achi is required during spermatogenesis.

                                        (Wang and Mann, 2003)

                                        aly-like meiotic arrest gene.

                                        (White-Cooper and Fuller, 1999)
                                        Relationship to Other Genes
                                        Source for database merge of
                                        Additional comments

                                        The zaa line is found to be a combination of two alleles visZ3922 and visZ3922.

                                        (Ayyar et al., 2003)
                                        Nomenclature History
                                        Source for database identify of

                                        Source for identity of: vismay CG8821

                                        (Ayyar, 2001.3.5)
                                        Nomenclature comments
                                        Etymology

                                        'vismay' is a Hindi word meaning 'surprise'.

                                        (Ayyar et al., 2003)

                                        "vismay" is Hindi for "surprise" - reflecting the surprise of the investigators upon discovering a tandem duplication in the genome which was the basis of the confusion surrounding the molecular analysis of achi.

                                        (Ayyar, 2001.3.5)
                                        Synonyms and Secondary IDs (9)
                                        Datasets (0)
                                        Study focus (0)
                                        Experimental Role
                                        Project
                                        Project Type
                                        Title
                                        Study result (0)
                                        Result
                                        Result Type
                                        Title
                                        External Crossreferences and Linkouts ( 40 )
                                        Sequence Crossreferences
                                        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                        Other crossreferences
                                        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                        FlyMine - An integrated database for Drosophila genomics
                                        InterPro - A database of protein families, domains and functional sites
                                        KEGG Genes - Molecular building blocks of life in the genomic space.
                                        MARRVEL_MODEL - MARRVEL (model organism gene)
                                        Linkouts
                                        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                        DroID - A comprehensive database of gene and protein interactions.
                                        DRSC - Results frm RNAi screens
                                        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                        Flygut - An atlas of the Drosophila adult midgut
                                        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                        MIST (protein-protein) - An integrated Molecular Interaction Database
                                        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                        References (78)