p63, p65
cytoskeletal protein - acts upstream of Arp2/3 which in turn mediates actin nucleation activity - functions downstream of Rho1 and the formin Cappuccino to control actin and microtubule dynamics during oogenesis - bundles and crosslinks F-actin and microtubules
Please see the JBrowse view of Dmel\wash for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.49
Component of the WASH complex (PubMed:20498093). Interacts with spir and capu (PubMed:19633175). Interacts (via N-terminus) with Rho1 (via N-terminus) (PubMed:25739458).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\wash using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
JBrowse - Visual display of RNA-Seq signals
View Dmel\wash in JBrowse2-66
2-67.4
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Identification: as a protein found in a Trf2-containing complex.
Source for identity of: wash CG13176
The gene symbol "wash" is an acronym formed from "Wiskott-Aldrich Syndrome Protein and SCAR Homolog".