FlyBase Gene Report: Dmel\CG1847

General Information

Symbol

Dmel\CG1847

Species

D. melanogaster

Name

Annotation Symbol

CG1847

Feature Type

protein_coding_gene

FlyBase ID

FBgn0030345

Gene Model Status

Current

Stock Availability

7 publicly available

Enzyme Name (EC)

peptidylprolyl isomerase (5.2.1.8)

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

10F2-10F2

Sequence location

X:11,869,170..11,871,168 [+]

Recombination map

1-37

RefSeq locus

NC_004354 REGION:11869170..11871168

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables peptidyl-prolyl cis-trans isomerase activity

inferred from electronic annotation with InterPro:IPR001179, InterPro:IPR046357

(InterPro Project Members, 2004-)

enables unfolded protein binding

inferred from sequence or structural similarity with UniProtKB:O00170

(Gene Ontology Curators, 2002-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in protein maturation by protein folding

inferred from sequence or structural similarity with UniProtKB:O00170

(Gene Ontology Curators, 2002-)

involved_in protein targeting to mitochondrion

inferred from sequence or structural similarity with UniProtKB:O00170

(Gene Ontology Curators, 2002-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in cytosol

inferred from sequence or structural similarity with UniProtKB:O00170

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

FK506-BINDING PROTEINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

peptidyl-prolyl cis-trans isomerase activity

[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) (5.2.1.8)

RHEA 16237:

Summaries

Gene Group (FlyBase)

FK506-BINDING PROTEINS -: FK506-binding proteins are a class of evolutionary conserved peptidyl prolyl cis/trans isomerases. In vertebrates, they form binary complexes with their ligand, FK506 or rapamycin, and are involved in key biochemical processes including protein folding, receptor signalling, protein trafficking, and transcription. FK506-binding proteins are characterized by the presence of a 'FKBP-type peptidyl-prolyl cis-trans isomerase domain' (IPR001179). (Adapted from PMID:25986569.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG1847 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A0A6H2EG45)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.44

Stop-codon suppression (UAG) postulated; FBrf0216884.

Gene model reviewed during 5.51

Double stop-codon suppression (UAG, UAG) postulated; FBrf0243886.

Gene model reviewed during 6.32

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011)

gene_with_stop_codon_read_through

(FlyBase Genome Annotators, 2019-, Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG1847-RA

FBtr0073567

NM_132530

1776

320

CG1847-RC

FBtr0330413

NM_167311

1776

342

CG1847-RD

FBtr0479842

NM_001382046

1776

390

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CG1847-PA

FBpp0073411

37.2

320

7.50

FBpp0303439

39.7

342

7.79

FBpp0428178

45.0

390

8.25

QJC18367

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG1847 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG1847_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.26

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 11 -- 12

procrystal cell

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval crystal cell

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG1847 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG1847

View exonic expression by tissue for Dmel\CG1847

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030345

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32144/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030345

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030345

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030345

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1847

Flygut - An atlas of the Drosophila adult midgut

FBgn0030345

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\CG1847

Stages(s) 1-3
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG1847

Transgenic constructs containing regulatory region of CG1847

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(1)Exel6243

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of larval stage | recessive

CG1847^exon1-3

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CG1847^GD9582

viable, with Scer\GAL4^Mef2.PR

CG1847^GD9582

viable, with Scer\GAL4^pnr-MD237

CG1847^GD9582

viable, with Scer\GAL4^tin.CΔ4

CG1847^GD9582

Other Phenotypes

Allele

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CG1847^GD9582

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (26)

Hsap\AIP

14 of 14

Yes

Hsap\AIPL1

12 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (18)

Rnor\Aip

14 of 14

Yes

Rnor\Aipl1

11 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (15)

Mmus\Aip

14 of 14

Yes

Mmus\Aipl1

11 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (13)

Xtro\aip

11 of 13

Yes

Xtro\ppid

2 of 13

Xtro\aipl1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (26)

Drer\aip

13 of 14

Yes

Drer\aipl1

12 of 14

Yes

Drer\LOC100534741

8 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC100537892

1 of 14

Drer\LOC103911146

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (10)

Cele\aipr-1

14 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (16)

Agam\AgaP_AGAP000725

12 of 12

Yes

Agam\AgaP_AGAP011684

12 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (24)

Atha\TPR6

2 of 13

Yes

Atha\TWD1

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (8)

Scer\CNS1

1 of 13

Yes

Scer\CPR6

1 of 13

Yes

Scer\CPR7

1 of 13

Yes

Scer\PPT1

1 of 13

Yes

Scer\SEC72

1 of 13

Yes

Scer\STI1

1 of 13

Yes

Scer\TOM70

1 of 13

Yes

Scer\TOM71

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\cns1

1 of 12

Yes

Spom\SPAC2F3.02

1 of 12

Yes

Spom\SPAC27F1.06c

1 of 12

Yes

Spom\SPBC3F6.01c

1 of 12

Yes

Spom\tom70

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CG1847. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (12)

1 of 13

1 of 13

1 of 13

1 of 13

Sgt

1 of 13

shu

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

zda

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

pituitary adenoma 1, multiple types

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

AIP; aryl hydrocarbon receptor interacting protein

model of pituitary adenoma 1

IEA

(FlyBase, 2019-)

AIPL1; aryl hydrocarbon receptor interacting protein like 1

model of Leber congenital amaurosis 4

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

AIP; aryl hydrocarbon receptor interacting protein

14 of 14

605555

PITUITARY ADENOMA 1, MULTIPLE TYPES; PITA1

pituitary adenoma 1

AIPL1; aryl hydrocarbon receptor interacting protein like 1

12 of 14

604392

LEBER CONGENITAL AMAUROSIS 4; LCA4

Leber congenital amaurosis 4

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

CG1847

Hsap\AIP

(Aflorei et al., 2018)

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

58549

DroID - A comprehensive database of gene and protein interactions.

FBgn0030345

MIST (protein-protein) - An integrated Molecular Interaction Database

32144

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Aryl hydrocarbon receptor signalling

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Aryl hydrocarbon receptor signalling

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-37

Cytogenetic map

10F2-10F2

Sequence location

X:11,869,170..11,871,168 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

10F2-10F2

Limits computationally determined from genome sequence between P{EP}ATP7^EP308 and P{EP}EP1451&P{EP}EP1629

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-37

(FlyBase, 2016)

1-36.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

32600

w^* P{EP}CG1847^G1839

76425

y¹ sc^* v¹ sev²¹; P{TKO.GS00595}attP40

77233

y¹ sc^* v¹ sev²¹; P{TOE.GS01047}attP40

44490

y¹ sc^* v¹ sev²¹; P{TRiP.HMC02409}attP2

NIG-Fly

HMC02409

y¹ sc^* v¹ sev²¹; P{TRiP.HMC02409}attP2

VDRC

v43701

w¹¹¹⁸; P{GD9582}v43701

v43702

w¹¹¹⁸; P{GD9582}v43702/TM3

Genomic Clones (9)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (18)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_HL02936

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0030345

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0030345

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

CG1847

(FlyBase Genome Annotators, 2019-, Aflorei et al., 2018, Ghartey-Kwansah et al., 2018, Transgenic RNAi Project members, 2017-, Liang et al., 2014, Luck et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Preall et al., 2012, Jungreis et al., 2011, Buffin and Gho, 2010, Ni et al., 2010.12.1, Gilfillan et al., 2007)

Name Synonyms

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 47 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32144

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0A6H2EG45

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A0A6H2EG45

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030345

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32144/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030345

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030345

FlyMine - An integrated database for Drosophila genomics

FBgn0030345

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1847

MARRVEL_MODEL - MARRVEL (model organism gene)

32144

Linkouts

BioGRID - A database of protein and genetic interactions.

58549

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0030345

DroID - A comprehensive database of gene and protein interactions.

FBgn0030345

DRSC - Results frm RNAi screens

FBgn0030345

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG1847_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030345

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0030345

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1847

Flygut - An atlas of the Drosophila adult midgut

FBgn0030345

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC002337

MIST (protein-protein) - An integrated Molecular Interaction Database

32144

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Aryl hydrocarbon receptor signalling

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Aryl hydrocarbon receptor signalling

References (40)

The following external sites may use different assemblies or annotations than FlyBase.

0.26

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