Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mdp-1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\Mdp-1 in JBrowsePlease Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Mdp-1 encodes a large proteoglycan molecule which is secreted exclusively by migratory embryonic hemocytes/macrophages.
Relationship of "Mdp-1" with "Ppn" is unclear; mAb 5H7 recognises "Mdp-1" protein in embryo protein extracts, and "Ppn" in Kc cell protein extracts. However biochemical analysis of the two proteins reveals a number of significant differences between the two molecules. "Ppn" and "Mdp-1" may therefore represent two different genes, or "Mdp-1" protein may be the naturally occurring form of "Ppn", which is secreted by Kc cells in culture.