Cd36
a member of the CD36 family of scavenger receptors - required for microbial phagocytosis and efficient bacterial clearance - booster for croquemort interacts with the zinc finger domain of the GATA transcription factor Serpent (Srp), to enhance its direct binding to the crq promoter; thus, Crq and Srp function together in regulating crq expression and efferocytosis, the action of removing apoptotic particles
Please see the JBrowse view of Dmel\crq for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.43
Gene model reviewed during 5.44
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
2.3 (compiled cDNA)
68 (kD observed); 54 (kD predicted)
N-glycosylated and/or O-glycosylated.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\crq using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: reported as crystal cell specific anlage
Comment: reported as plasmatocytes anlage
Comment: 96-120 hr AEL
Comment: 96-120 hr AEL
Comment: 96-120 hr AEL
Comment: 120 hr AEL
Comment: 120 hr AEL
Comment: 120 hr AEL
Comment: 120 hr AEL
Comment: 120 hr AEL
Comment: expression starts late in embryonic stage 11
Expression of crq protein is observed in cytoplasm of dying salivary gland cells starting at 14 hours APF.
croquemort protein is detected in hemocytes starting at late stage 11 of embryogenesis.
JBrowse - Visual display of RNA-Seq signals
View Dmel\crq in JBrowse2-0.7
2-0.0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
New annotation (CG31655) in release 3 of the genome annotation. CG31655 merged into CG4280 in release 3 of the genome annotation, October 2002.
crq is essential for the phagocytosis of apoptotic corpses but not required for the engulfment of bacteria.
Encodes a macrophage receptor for apoptotic cells.
Source for merge of: crq anon-WO0140519.8
Source for merge of crq anon-WO0140519.8 was sequence comparison ( date:051113 ).
Source for identity of: crq CG4280