FlyBase Gene Report: Dmel\Cks30A

FB2024_03 , released June 25, 2024

FB2024_03 , released June 25, 2024

Gene: Dmel\Cks30A

General Information

Symbol

Dmel\Cks30A

Species

D. melanogaster

Name

Cyclin-dependent kinase subunit 30A

Annotation Symbol

CG3738

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010314

Gene Model Status

Stock Availability

15 publicly available

Gene Summary

Cyclin-dependent kinase subunit 30A (Cks30A) encodes a protein that promotes progression through female meiosis and the mitotic divisions of the early embryo. It interacts with the product of Cdk1 and is required in prometaphase for spindle assembly, and at the metaphase to anaphase transition for the destruction of the cyclin encoded by CycA. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
UniProtKB
Red Book
Interactive Fly

Also Known As

Cks, rem, Cdi2, remnants

Key Links

Genomic Location

Cytogenetic map

Sequence location

2L:9,330,763..9,331,981 [+]

Recombination map

2-35

RefSeq locus

NT_033779 REGION:9330763..9331981

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (16 terms)

Molecular Function (6 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with FLYBASE:Cdk1; FB:FBgn0004106

(Finley et al., 1996)

inferred from physical interaction with FLYBASE:Cdk2; FB:FBgn0004107

(Finley et al., 1996)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

enables cyclin-dependent protein serine/threonine kinase activator activity

inferred from biological aspect of ancestor with PANTHER:PTN000602176

(GO Reference Genome Project, 2011-)

enables cyclin-dependent protein serine/threonine kinase regulator activity

inferred from electronic annotation with InterPro:IPR000789, InterPro:IPR036858

(InterPro Project Members, 2004-)

enables histone binding

inferred from biological aspect of ancestor with PANTHER:PTN000602176

(GO Reference Genome Project, 2011-)

enables protein kinase binding

inferred from biological aspect of ancestor with PANTHER:PTN000602176

(GO Reference Genome Project, 2011-)

enables ubiquitin binding

inferred from biological aspect of ancestor with PANTHER:PTN000602176

(GO Reference Genome Project, 2011-)

Biological Process (8 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

involved_in anaphase-promoting complex-dependent catabolic process

inferred from mutant phenotype

(Swan and Schupbach, 2007)

involved_in female meiosis I

inferred from mutant phenotype

(Pearson et al., 2005)

involved_in female meiotic nuclear division

inferred from mutant phenotype

(Swan and Schupbach, 2007)

involved_in histoblast morphogenesis

inferred from mutant phenotype

(Swan et al., 2005)

involved_in spindle assembly involved in female meiosis I

inferred from mutant phenotype

(Pearson et al., 2005)

involved_in spindle assembly

inferred from mutant phenotype

(Swan et al., 2005)

involved_in syncytial blastoderm mitotic cell cycle

inferred from mutant phenotype

(Swan et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of mitotic cell cycle

inferred from biological aspect of ancestor with PANTHER:PTN000602176

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of cyclin-dependent protein kinase holoenzyme complex

inferred from biological aspect of ancestor with PANTHER:PTN000602176

(GO Reference Genome Project, 2011-)

part_of SCF ubiquitin ligase complex

inferred from biological aspect of ancestor with PANTHER:PTN000602176

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the CKS family. (Q24152)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Cyclin-dependent kinase subunit 30A (Cks30A) encodes a protein that promotes progression through female meiosis and the mitotic divisions of the early embryo. It interacts with the product of Cdk1 and is required in prometaphase for spindle assembly, and at the metaphase to anaphase transition for the destruction of the cyclin encoded by CycA. [Date last reviewed: 2019-03-21]

Protein Function (UniProtKB)

Binds to the catalytic subunit of the cyclin dependent kinases Cdk1 and Cdk2, and is essential for their biological function.

(UniProt, Q24152)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

rem: remnants (T. Schupbach)

Maternal effect lethal; eggs laid by females homozygous for rem1 show no visible sign of development when observed under transmitted light in stereomicroscope; eggs derived from rem2 often allow embryonic development; those embryos form fragmented cuticle with variable holes and head defects.

Summary (Interactive Fly)

Cyclin-dependent kinase regulatory subunit required for progression through female meiosis and the mitotic divisions of the early embryo through an interaction with Cdk1 (Cdc2)

Interactive Fly

Gene Model and Products

Number of Transcripts

1

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\Cks30A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q24152)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0079799

1147

74

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0079399

9.1

74

9.35

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

74 (aa)

(Finley et al., 1996)

Comments

External Data

Subunit Structure (UniProtKB)

Forms a homohexamer that can probably bind six kinase subunits.

(UniProt, Q24152)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Q24152

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cks30A using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Cks30A_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.17

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cks30A in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cks30A

View exonic expression by tissue for Dmel\Cks30A

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34250/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010314

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010314

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010314

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3738

Flygut - An atlas of the Drosophila adult midgut

FBgn0010314

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cks30A

Transgenic constructs containing regulatory region of Cks30A

Aberrations (Deficiencies and Duplications) ( 15 )

Inferred from experimentation ( 15 )

Gene disrupted in

(Pearson et al., 2005, Lane and Kalderon, 1993, Schupbach and Wieschaus, 1989)

(Kahsai and Cook, 2018, Pearson et al., 2005)

(Kahsai and Cook, 2018)

(Lane and Kalderon, 1993)

(Lane and Kalderon, 1993)

(Lane and Kalderon, 1993)

(Pearson et al., 2005)

(Lane and Kalderon, 1993)

Gene not disrupted in

(Lane and Kalderon, 1993)

(Lane and Kalderon, 1993)

(Pearson et al., 2005)

(Pearson et al., 2005)

(Pearson et al., 2005)

(Pearson et al., 2005, Lane and Kalderon, 1993)

(Lane and Kalderon, 1993)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | maternal effect

lethal - all die during embryonic stage | non-rescuable maternal effect | recessive

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Cks30A^GD13692

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Cks30A^GD13692

viable, with Scer\GAL4^Mef2.PR

Cks30A^GD13692

Sterility

Allele

female sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

Cks30A^GL00024

female sterile (with Df(2L)ED673)

Cks30A^RA74

female sterile (with Df(2L)ED678)

Cks30A^RA74

female sterile | recessive

Other Phenotypes

Allele

abnormal meiotic cell cycle

Cks30A^KO

abnormal meiotic cell cycle | female

Cks30A^KO

abnormal meiotic cell cycle | female limited

abnormal mitotic cell cycle | embryonic stage

some die during embryonic stage | recessive

some die during pupal stage, with Scer\GAL4^pnr-MD237

Cks30A^GD13692

Phenotype manifest in

Allele

Cks30A^KO

aster & oocyte

embryo | maternal effect, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

Cks30A^GL00024

embryonic/first instar larval cuticle

Cks30A^HG24

larval cuticle & larval abdomen

larval cuticle & larval abdomen (with Cks30A^HG24)

Cks30A^RA74

larval cuticle & larval abdomen (with Cks30A^KO)

Cks30A^RA74

larval cuticle & larval abdomen (with Cks30A^RA74)

Cks30A^KO

spindle & oocyte

Cks30A^RA74

spindle pole centrosome

Cks30A^KO

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (2)

12 of 14

Yes

Yes

1

10 of 14

No

Yes

1

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (4)

12 of 14

Yes

Yes

11 of 14

No

Yes

10 of 14

No

Yes

Rnor\LOC120102505

7 of 14

No

Yes

Mus musculus (laboratory mouse) (3)

12 of 14

Yes

Yes

11 of 14

No

Yes

10 of 14

No

Yes

Xenopus tropicalis (Western clawed frog) (3)

3 of 13

Yes

No

2 of 13

No

Yes

2 of 13

No

No

Danio rerio (Zebrafish) (3)

12 of 14

Yes

Yes

12 of 14

Yes

Yes

10 of 14

No

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

12 of 14

Yes

No

Cele\Y71G12B.27

6 of 14

No

Yes

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP009442

12 of 12

Yes

Yes

Agam\AgaP_AGAP003796

6 of 12

No

No

Arabidopsis thaliana (thale-cress) (2)

13 of 13

Yes

Yes

13 of 13

Yes

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

10 of 13

Yes

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

9 of 12

Yes

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Cks30A. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (3)

11 of 13

2 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CKS1B; CDC28 protein kinase regulatory subunit 1B

12 of 14

CKS2; CDC28 protein kinase regulatory subunit 2

10 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

On

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, western blot, experimental knowledge based, two hybrid

(Ghorbani et al., 2011, Guruharsha et al., 2011, Swan et al., 2005, Finley et al., 1996)

anti tag coimmunoprecipitation, western blot

(Swan et al., 2005)

Cks30A - Cks85A

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

anti tag coimmunoprecipitation, western blot, experimental knowledge based

(Guruharsha et al., 2011, Swan et al., 2005)

experimental knowledge based, anti tag coimmunoprecipitation, western blot

(Guruharsha et al., 2011, Swan et al., 2005)

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Swan et al., 2005)

suppressible

(Swan et al., 2005)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Swan et al., 2005)

suppressible

(Ghorbani et al., 2011)

suppressible

(Swan and Schupbach, 2007)

External Data

Subunit Structure (UniProtKB)

Forms a homohexamer that can probably bind six kinase subunits.

(UniProt, Q24152 )

Linkouts

BioGRID - A database of protein and genetic interactions.

60354

DroID - A comprehensive database of gene and protein interactions.

FBgn0010314

MIST (genetic) - An integrated Molecular Interaction Database

34250

MIST (protein-protein) - An integrated Molecular Interaction Database

34250

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2L

Recombination map

2-35

Cytogenetic map

Sequence location

2L:9,330,763..9,331,981 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

30A8-30A8

Limits computationally determined from genome sequence between P{PZ}tai⁰¹³⁵¹ and P{PZ}scat¹&P{PZ}numb⁰³²³⁵

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

30A-30A

(Swan, 2005.3.7)

30A7-30A8

(determined by in situ hybridisation)

(Celniker, 1998.11.30, BDGP Project Members, 1994-1999)

Location inferred from in situ hybridisation using clone DS06478.

(Celniker, 1998.11.30)

Experimentally Determined Recombination Data

Location

2-35

(FlyBase, 2016)

2-30.2

(Comeron et al., 2012)

2-32

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (15)

Aberrations including deletions of this gene Aberrations including duplications of this gene

59055

w^*; P{UAS-Cks30A.R}3

21810

y¹ w^67c23; P{Mae-UAS.6.11}Cks30A^DP00300

5104

Cks30A^RA74 cn¹ bw¹/CyO, l(2)DTS513¹

35156

y¹ sc^* v¹ sev²¹; P{TRiP.GL00024}attP2

81990

y¹ sc^* v¹ sev²¹; P{TKO.GS04206}attP40

108044

Cks30A^RA74 cn¹ bw¹/CyO, l(2)DTS513¹

M2L-1604

y¹ w¹¹¹⁸; Cks30A^SK3 P{neoFRT}40A/CyO-Tb

M2L-1605

y¹ w¹¹¹⁸; Cks30A^SK5 P{neoFRT}40A/CyO-Tb

GL00024

y¹ sc^* v¹ sev²¹; P{TRiP.GL00024}attP2

v330385

P{VSH330385}attP40

v108401

P{KK109062}VIE-260B

v341706

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00813}attP40/CyO-GFP

More stocks available...

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (75)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD20271

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010314

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010314

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Cks30A has a role in the metaphase to anaphase transition in female meiosis and in the mitotic divisions of the syncytial embryo.

(Swan and Schupbach, 2005)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Isolated by interaction with cdc2 and cdc2c using the interaction trap two hybrid system.

(Finley et al., 1996)

Yeast two-hybrid system has been used to characterise Cyclin-dependent kinase interactor proteins (the prey) in hunts with either cdc2 or cdc2c as baits. Cks30A interacts with cdc2 cdc2c and CycJ, and other human and S.cerevisiae cyclin-dependent kinases to activate transcription of a reporter gene, Ecol\lacZ.

(Finley and Brent, 1994)

The yeast interaction trap selection has been used to isolate cell cycle regulatory proteins that interact with cdc2 and cdc2c. Cks30A interacts with cdc2 and cdc2c.

(Finley and Brent, 1993)

Mutations in Cks30A show a strict maternal effect phenotype with defects during presyncytial stages.

(Schupbach and Wieschaus, 1989)

Relationship to Other Genes

Source for database merge of

Source for merge of: Cks30A rem

(Swan et al., 2005)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Cks30A Cks

(Swan, 2005.3.7)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

CDI2

(Finley and Brent, 1993)

CG3738

(National Institute of Genetics Fly Stocks, 2022-, Meadows, 2017.9.14, Guven-Ozkan et al., 2016, Ellis and Carney, 2011, Ni et al., 2011.7.19, Zhang et al., 2011, Keleman et al., 2009.8.5, Perkins et al., 2009, Liu et al., 2005, Pearson et al., 2005)

Cdi2

(Zhong et al., 2003, Breitwieser et al., 1996, Finley et al., 1996)

Cks

(Hueber et al., 2007, Ren et al., 2005, Asha et al., 2003, Giot et al., 2003, Finley and Brent, 1994)

Cks30A

(Khalili et al., 2023, Ferguson et al., 2021, Williams et al., 2020, Transgenic RNAi Project members, 2017-, Das et al., 2016, Guven-Ozkan et al., 2016, Richardson, 2015.3.11, Sopko et al., 2014, Korenjak et al., 2012, Ellis and Carney, 2011, Ghorbani et al., 2011, Georlette et al., 2007, Swan and Schüpbach, 2007, Swan and Schupbach, 2007, Liu et al., 2005)

DmCks1

U40077

(Celniker, 1998.11.30)

cdi2

cks

(Gao et al., 2008)

cks30A

(Hughes et al., 2018, Sopko et al., 2014, Swan and Schupbach, 2005)

fs(2)rem

(Lane and Kalderon, 1993)

rem

(Pearson et al., 2005, Bloomington Drosophila Stock Center, 1999.2.28, Foe et al., 1993, Schupbach and Wieschaus, 1989)

Name Synonyms

Cyclin-dependent kinase interactor 2

Cyclin-dependent kinase subunit 30A

(Swan, 2005.3.7)

remnants

(Swan and Schupbach, 2007, Pearson et al., 2005)

Secondary FlyBase IDs

FBgn0003235

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 39 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34250

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q24152

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q24152

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q24152

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34250/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010314

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010314

FlyMine - An integrated database for Drosophila genomics

FBgn0010314

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG3738

MARRVEL_MODEL - MARRVEL (model organism gene)

34250

Linkouts

BioGRID - A database of protein and genetic interactions.

60354

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010314

DroID - A comprehensive database of gene and protein interactions.

FBgn0010314

DRSC - Results frm RNAi screens

FBgn0010314

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Cks30A_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010314

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010314

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3738

Flygut - An atlas of the Drosophila adult midgut

FBgn0010314

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0010314

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC033819

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

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MIST (protein-protein) - An integrated Molecular Interaction Database

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Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (78)