FB2024_03 , released June 25, 2024
Gene: Dmel\elB
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General Information
Symbol
Dmel\elB
Species
D. melanogaster
Name
elbow B
Annotation Symbol
CG4220
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004858
Gene Model Status
Current
Stock Availability
45 publicly available
Gene Summary
May negatively regulate Notch-induced cell proliferation in the eye-head primordium. May act in leg and wing primordia to negatively regulate body-wall specifying genes and thereby promote appendage formation. Required for tracheal development. (UniProt, Q9VJS8)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

el, elbow, BG:DS06238.3

Key Links
Genomic Location
Cytogenetic map
35B1-35B1
Sequence location
Recombination map
2-50
RefSeq locus
NT_033779 REGION:14390628..14409549
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with FLYBASE:gro; FB:FBgn0001139
(Dorfman et al., 2002)
inferred from physical interaction with FLYBASE:noc; FB:FBgn0005771
(Dorfman et al., 2002)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (8 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in compound eye photoreceptor fate commitment
inferred from genetic interaction with FLYBASE:noc; FB:FBgn0005771
(Wernet et al., 2014)
involved_in eye-antennal disc development
inferred from mutant phenotype
(Luque and Milan, 2007)
involved_in imaginal disc-derived appendage development
inferred from mutant phenotype
(Weihe et al., 2004)
involved_in negative regulation of gene expression
inferred from mutant phenotype
(Dorfman et al., 2002)
involved_in open tracheal system development
inferred from mutant phenotype
(Dorfman et al., 2002)
involved_in wing disc development
inferred from mutant phenotype
(Weihe et al., 2004)
NOT involved_in leg disc development
inferred from mutant phenotype
(Weihe et al., 2004)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in negative regulation of DNA-templated transcription
inferred from biological aspect of ancestor with PANTHER:PTN000968869
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in nuclear chromosome
inferred from direct assay
(Singari et al., 2014)
located_in nucleus
inferred from direct assay
(Dorfman et al., 2002)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000968869
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the Elbow/Noc family. (Q9VJS8)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
UNCLASSIFIED DNA BINDING DOMAIN TRANSCRIPTION FACTORS -
This group comprises DNA-binding transcription factors that do not classify under other domain-based transcription factor groups in FlyBase.
Protein Function (UniProtKB)
May negatively regulate Notch-induced cell proliferation in the eye-head primordium. May act in leg and wing primordia to negatively regulate body-wall specifying genes and thereby promote appendage formation. Required for tracheal development.
(UniProt, Q9VJS8)
Summary (Interactive Fly)

zinc finger transcription factor - specifies distinct tracheal cell fates - interacts with the transcription factor Orthodenticle, a crucial regulator of rhodopsin gene transcription

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\elB for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VJS8)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
elB-RC
FBtr0080637
NM_205990
3323
552
elB-RD
FBtr0342915
NM_078842
3326
553
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
elB-PC
FBpp0089383
55.7
552
9.23
NP_995712
AAS64707
elB-PD
FBpp0309706
55.9
553
9.23
Q9VJS8
NP_523566
AAF53395
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Self-associates. Interacts with gro and noc.

(UniProt, Q9VJS8)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\elB using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.22

Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
second instar larval stage
eye-antennal disc | restricted
(Luque and Milan, 2007)
third instar larval stage
eye-antennal disc | restricted
(Luque and Milan, 2007)
early third instar larval stage
eye-antennal disc | anterior
(Luque and Milan, 2007)
late third instar larval stage
eye disc anterior to the morphogenetic furrow
(Luque and Milan, 2007)
Additional Descriptive Data

In second instar eye-antenna discs, elB and noc reporter expression is restricted to the eye primordium. In early third instar discs, expression in the distal part of the antenna primordium is observed. In the eye-head primordium, elB and noc are expressed in the hth domain that indicates the proliferative region. In late third instar larval discs, expression levels remain high in the region anterior to the morphogenetic furrow, at more elevated levels in cells that co-express hth and tsh and at lower levels in the pre-proneural region. Thus elB and noc are expressed at higher levels in the proliferative region of the eye-head primordium.

(Luque and Milan, 2007)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nuclear chromosome
inferred from direct assay
(Singari et al., 2014)
located_in nucleus
inferred from direct assay
(Dorfman et al., 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\elB in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 40 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of elB
Transgenic constructs containing regulatory region of elB
Aberrations (Deficiencies and Duplications) ( 126 )
Inferred from experimentation ( 126 )
Gene disrupted in
Df(2L)A47
(Roote et al., 1996, Fossett et al., 1994)
Df(2L)A215
(Fossett et al., 1994)
Df(2L)A217
(Roote, 1998.11.16, Fossett et al., 1994)
Df(2L)A246
(Fossett et al., 1994)
Df(2L)A337
(Fossett et al., 1994)
Df(2L)A376
(Fossett et al., 1994)
Df(2L)A400
(Davis et al., 1997, Roote et al., 1996, Fossett et al., 1994, Davis et al., 1990)
Df(2L)Adh-nBR100
(Fossett et al., 1994)
Df(2L)Adh-nBR101
(Fossett et al., 1994)
Df(2L)Adh-nBR103
(Fossett et al., 1994)
Df(2L)Adh-nBR117
(Fossett et al., 1994)
Df(2L)Adh-nBR120
(Fossett et al., 1994)
Df(2L)Adh-nBR125
(Fossett et al., 1994)
Df(2L)Adh-nBR130
(Fossett et al., 1994)
Df(2L)Adh-nBR131
(Fossett et al., 1994)
Df(2L)b81a1
(Roote et al., 1996)
Df(2L)b83d29a
(Davis et al., 1997, Roote et al., 1996, Davis et al., 1990)
Df(2L)b84a2
(Davis et al., 1997, Roote et al., 1996, Davis et al., 1990)
Df(2L)b84a4
(Roote et al., 1996)
Df(2L)b88h49
(Roote, 1996.8, Roote et al., 1996)
Df(2L)el16
(Davis et al., 1990)
Df(2L)el94
(Roote, 1996.1.11, Roote, 1996.8)
Df(2L)EP(2)2039-rv3
(Roote, 2000.6.13)
Df(2L)EP(2)2039-rv4
(Roote, 2000.6.13)
Df(2L)Exel6035
(Ryder, 2004.4.26)
Df(2L)fn1
(Grau et al., 1984)
Df(2L)fn2
(Dorfman et al., 2002)
Df(2L)noc10
(Dorfman et al., 2002)
Df(2L)ppk1MirB
(Wegman et al., 2010)
Df(2L)ppkESB
(Boiko et al., 2012)
Df(2L)Scorv23
(Grau et al., 1984)
Df(2L)TE35B-1
(Gubb et al., 1985)
Df(2L)TE35B-2
(Gubb et al., 1985)
Df(2L)TE35B-3
(Gubb et al., 1985)
Df(2L)TE35B-4
(Gubb et al., 1985)
Df(2L)TE35B-5
(Gubb et al., 1985)
Df(2L)TE35B-6
(Gubb et al., 1985)
Df(2L)TE35B-7
(Davis et al., 1997, Roote et al., 1996, Davis et al., 1990, Gubb et al., 1985)
Df(2L)TE35B-8
(Roote et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-9
(Gubb et al., 1985)
Df(2L)TE35B-10
(Gubb et al., 1985)
Df(2L)TE35B-12
(Gubb et al., 1985)
Df(2L)TE35B-15
(Gubb et al., 1985)
Df(2L)TE35B-300
(Roote et al., 1996)
In(2L)75c
(Grau et al., 1984)
In(2L)el94
(Roote, 1998.3.17)
In(2L)el9
(Davis et al., 1997, Roote et al., 1996, Davis et al., 1990)
In(2L)TE35B-13
(Davis et al., 1997, Roote, 1996.8, Roote et al., 1996, Gubb et al., 1985)
In(2LR)D20Lnoc4R
(Roote et al., 1996)
In(2LR)el6
(Davis et al., 1997, Davis et al., 1990)
In(2LR)el6LA379R
(Roote, 1996.1.11)
T(2;3)dpps19
(Davis et al., 1997, Roote et al., 1996, Davis et al., 1990)
T(Y;2)a15
(Davis et al., 1997, Roote et al., 1996, Davis et al., 1990)
T(Y;2)el4
(Davis et al., 1997, Roote et al., 1996, Davis et al., 1990)
T(Y;2)GT2
(Davis et al., 1990)
Ts(2Lt;3Lt)dpps19+Ts(2Rt;3Rt)el24
(Roote, 1996.1.11, Roote et al., 1996, Roote, 1995.3.27)
Ts(2Lt;3Rt)GT10+Ts(2Rt;3Lt)TE35B-209
(Roote et al., 1996)
Ts(Y;2Lt)a15+Ts(YSt;2Rt)A80
(Roote, 1996.1.11, Roote et al., 1996, Roote, 1995.3.27)
Ts(Y;2Lt)el4+Ts(YSt;2Rt)A80
(Roote, 1996.1.11, Roote et al., 1996)
Ts(Y;2Lt)el4+Ts(YSt;2Rt)R15
(Roote, 1996.1.11, Roote et al., 1996)
Ts(Y;2Lt)GT2+Ts(YSt;2Rt)A80
(Davis et al., 1997, Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996)
Gene not disrupted in
Df(2L)A48
(Roote et al., 1996, BDGP Project Members, 1994-1999, Fossett et al., 1994, Grau et al., 1984)
Df(2L)A63
(Roote et al., 1996, Fossett et al., 1994)
Df(2L)A72
(Fossett et al., 1994)
Df(2L)A178
(Davis et al., 1997, Roote et al., 1996, Fossett et al., 1994)
Df(2L)A220
(Fossett et al., 1994)
Df(2L)A245
(Roote et al., 1996, Fossett et al., 1994, Davis et al., 1990)
Df(2L)A260
(Davis et al., 1990)
Df(2L)A264
(Fossett et al., 1994)
Df(2L)A266
(Fossett et al., 1994, Davis et al., 1990)
Df(2L)A267
(Roote et al., 1996, Fossett et al., 1994)
Df(2L)A379
(Fossett et al., 1994)
Df(2L)A445
(Roote et al., 1996, Fossett et al., 1994)
Df(2L)Adh-nBR102
(Roote et al., 1996, Fossett et al., 1994)
Df(2L)Adh-nBR105
(Fossett et al., 1994)
Df(2L)Adh-nBR106
(Fossett et al., 1994)
Df(2L)Adh-nBR107
(Fossett et al., 1994)
Df(2L)Adh-nBR118
(Fossett et al., 1994)
Df(2L)Adh-nBR119
(Fossett et al., 1994)
Df(2L)Adh-nBR121
(Fossett et al., 1994)
Df(2L)Adh-nBR122
(Fossett et al., 1994)
Df(2L)Adh-nBR126
(Fossett et al., 1994)
Df(2L)Adh-nBR127
(Fossett et al., 1994)
Df(2L)Adh-nBR128
(Fossett et al., 1994)
Df(2L)Adh-nBR129
(Fossett et al., 1994)
Df(2L)ARR1
(Roote et al., 1996, Davis et al., 1990)
Df(2L)b80e3
(Roote et al., 1996)
Df(2L)ED3
(Ryder and Roote, 2004.11.10, Roote, 2002.2.6)
Df(2L)el14
(Davis et al., 1997, Roote et al., 1996)
Df(2L)el16
(Davis et al., 1997)
Df(2L)el28
(Davis et al., 1997, Davis et al., 1990)
Df(2L)fn2
(Davis et al., 1997, Roote et al., 1996)
Df(2L)fn3
(Davis et al., 1997, Davis et al., 1990)
Df(2L)fn27
(Davis et al., 1997)
Df(2L)n78l3
(Davis et al., 1997)
Df(2L)osp29
(Roote et al., 1996, Grau et al., 1984)
Df(2L)osp144
(Roote et al., 1996)
Df(2L)ppkESB
(Boiko et al., 2012)
Df(2L)Scorv10
(Grau et al., 1984)
Df(2L)Scorv16
(Grau et al., 1984)
Df(2L)Scorv19
(Grau et al., 1984)
Df(2L)Scorv25
(Grau et al., 1984)
Df(2L)SS1
(Grau et al., 1984)
Df(2L)TE35B-1
(Davis et al., 1997, Davis et al., 1990)
Df(2L)TE35B-6
(Davis et al., 1997, Davis et al., 1990)
Df(2L)TE35B-11
(Roote et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-12
(Roote, 1996.8, Roote et al., 1996)
Df(2L)TE35B-54L
(Roote et al., 1996)
Df(2L)TE35BC-3
(Grau et al., 1984)
Df(2L)TE35BC-4
(Roote et al., 1996)
Df(2L)TE35BC-8
(Davis et al., 1997, Davis et al., 1990)
Dp(2;2)Cam12
(Roote et al., 1996)
In(2L)75c
(BDGP Project Members, 1994-1999)
In(2LR)DTD128
(Davis et al., 1990)
In(2LR)el6LA379R
(Roote et al., 1996)
T(2;3)el24
(Davis et al., 1990)
T(2;3)GT8
(Davis et al., 1990)
T(2;3)GT10
(Davis et al., 1990)
T(2;3)Scorv7
(Grau et al., 1984)
T(Y;2)A80
(Davis et al., 1990)
T(Y;2)GT2
(Roote et al., 1996)
Tp(2;2)A446
(Davis et al., 1997, Roote et al., 1996, Fossett et al., 1994)
Tp(2;3)GT3
(Roote et al., 1996, Davis et al., 1990)
Ts(2Lt;3Lt)TE35B-28+Ts(2Rt;3Rt)osp90
(Roote et al., 1996)
Ts(Y;2Lt)TE35B-18+Ts(YSt;2Rt)R15
(Davis et al., 1990)
Gene duplicated in
Dp(2;1)Scorv23
(Grau et al., 1984)
Ts(2Lt;4Lt)TE35B-101+Ts(2Rt;4Rt)GT6
(Roote et al., 1996)
Ts(YLt;2Lt)A80+Ts(YLt;2Rt)G74
(Roote et al., 1996)
Gene not duplicated in
Dp(2;2)TE35B-54L
(Roote et al., 1996)
Dp(2;3)osp3
(Roote et al., 1996)
In(2L)C163.41LC158R
(Roote et al., 1996)
In(2LR)TE35B-226LDTD128R
(Roote et al., 1996)
Ts(Y;2Lt)TE35B-18+Ts(YSt;2Rt)A80
(Roote et al., 1996)
Ts(YLt;2Lt)R15+Ts(Y;2Rt)TE35B-18
(Roote et al., 1996)
Ts(YLt;2Lt)R15+Ts(YSt;2Rt)A80
(Roote et al., 1996)
Gene partially disrupted in
In(2LR)el6LA379R
(Roote, 1996.8)
Ts(2Lt;3Lt)dpps19+Ts(2Rt;3Rt)el24
(Roote, 1996.8)
Ts(Y;2Lt)a15+Ts(YSt;2Rt)A80
(Roote, 1996.8)
Ts(Y;2Lt)el4+Ts(YSt;2Rt)A80
(Roote, 1996.8)
Ts(Y;2Lt)el4+Ts(YSt;2Rt)R15
(Roote, 1996.8)
Inferred from location ( 0 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4btl.PS
lethal, with Scer\GAL4en-e16E
lethal (with Df(2L)A400)
lethal (with Df(2L)el28)
lethal (with Df(2L)TE35B-1)
lethal (with Df(2L)TE35B-6)
lethal (with Df(2L)TE35B-7)
lethal (with Df(2L)TE35BC-8)
lethal (with In(2L)TE35B-13)
lethal | male limited, with Scer\GAL4Bx-MS1096
lethal | male limited | cold sensitive, with Scer\GAL4Bx-MS1096
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
partially lethal
viable
viable (with Df(2L)Exel6035)
Sterility
Allele
fertile
Other Phenotypes
Allele
some die during pupal stage, with Scer\GAL4pnr-MD237
visible
visible, with Scer\GAL4ap-md544
visible, with Scer\GAL4Bx-MS1096-KE
visible, with Scer\GAL4en-e16E
visible, with Scer\GAL4ey.PH
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4sca-537.4
visible | female limited, with Scer\GAL4Bx-MS1096
visible | female limited | cold sensitive, with Scer\GAL4Bx-MS1096
visible | heat sensitive
visible | recessive
Phenotype manifest in
Allele
2nd posterior cell
adult thorax, with Scer\GAL4ap-md544
alula
alula & macrochaeta
dorsal tracheal branch primordium
dorsal tracheal branch primordium, with Scer\GAL4btl.PS
dorsocentral bristle, with Scer\GAL4ap-md544
dorsocentral bristle | ectopic, with Scer\GAL4sca-537.4
dorsocentral bristle | increased number, with Scer\GAL4ap-md544
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4GMR.PF
ganglionic tracheal branch primordium
retina, with Scer\GAL4GMR.long
scutellar bristle, with Scer\GAL4ap-md544
scutellar bristle | ectopic, with Scer\GAL4sca-537.4
scutellar bristle | increased number, with Scer\GAL4ap-md544
tracheal lateral trunk anterior branch primordium
tracheal transverse connective primordium
tracheal transverse connective primordium, with Scer\GAL4btl.PS
visceral tracheal branch primordium, with Scer\GAL4btl.PS
wing
wing, with Scer\GAL4Bx-MS1096-KE
wing | female limited, with Scer\GAL4Bx-MS1096
wing | female limited | cold sensitive, with Scer\GAL4Bx-MS1096
wing | posterior
wing vein, with Scer\GAL4en-e16E
wing vein L5
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (2)
Hsap\ZNF503
10 of 14
Yes
No
2  
Hsap\ZNF703
10 of 14
Yes
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (2)
Rnor\Zfp503
9 of 14
Yes
No
Rnor\Zfp703
9 of 14
Yes
No
Mus musculus (laboratory mouse) (2)
Mmus\Zfp503
9 of 14
Yes
No
Mmus\Zfp703
8 of 14
No
No
Xenopus tropicalis (Western clawed frog) (4)
Xtro\znf503
8 of 13
Yes
No
Xtro\znf703
8 of 13
Yes
No
Xtro\hectd3
1 of 13
No
Yes
Xtro\LOC100488559
1 of 13
No
No
Danio rerio (Zebrafish) (3)
Drer\znf503
10 of 14
Yes
No
Drer\znf703
10 of 14
Yes
No
Drer\LOC100333111
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\tlp-1
5 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP010223
5 of 12
Yes
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:elB. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (1)
noc
10 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ZNF503; zinc finger protein 503
    10 of 14
    613902
         
        ZNF703; zinc finger protein 703
        10 of 14
        617045
             
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Show/hide secondary interactors 
            (data from AllianceMine provided by esyN)
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Other Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            elB
            pull down, autoradiography
            (Dorfman et al., 2002)
            elB - CG12084
            anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
            (Rhee et al., 2014)
            elB - CG2889
            two hybrid array
            (Shokri et al., 2019)
            elB - Eip78C
            two hybrid array
            (Shokri et al., 2019)
            elB - Hr78
            two hybrid array
            (Shokri et al., 2019)
            elB - Myb
            two hybrid array
            (Shokri et al., 2019)
            elB - gro
            pull down, autoradiography
            (Dorfman et al., 2002)
            elB - noc
            pull down, autoradiography
            (Dorfman et al., 2002)
            Summary of Genetic Interactions
            esyN Network Diagram
            Show/hide secondary interactors 
            (data from AllianceMine provided by esyN)
            esyN Network Key:
            Suppression
            Enhancement
            Other Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            elB
            suppressible
            CycE
            (Tseng and Hariharan, 2002)
            noc|elB
            suppressible
            mam
            (Luque and Milan, 2007)
            noc|elB
            suppressible
            N
            (Luque and Milan, 2007)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            pnr
            enhanceable
            elB
            (Pena-Rangel et al., 2002)
            sna
            enhanceable
            elB
            (Ashburner et al., 1999, Davis et al., 1997)
            External Data
            Subunit Structure (UniProtKB)
            Self-associates. Interacts with gro and noc.
            (UniProt, Q9VJS8 )
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            External Data
            Linkouts
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2L
            Recombination map
            2-50
            Cytogenetic map
            35B1-35B1
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            35B1-35B1
            Limits computationally determined from genome sequence between P{lacW}l(2)34Fak00811&P{PZ}wb09437 and P{EP}elBEP2039&P{PZ}osprJ571
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            35B1-35B2
            (determined by in situ hybridisation)
            (Ashburner et al., 1999, Spradling et al., 1999)
            Experimentally Determined Recombination Data
            Location

            2-50

            (FlyBase, 2016)

            2-46.5

            (Comeron et al., 2012)

            2-50.0

            (Lindsley and Zimm, 1992)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (45)
            Genomic Clones (31)
            cDNA Clones (61)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            Antibody Information
            Laboratory Generated Antibodies
             

            polyclonal

            (Dorfman et al., 2002)
            Commercially Available Antibodies
             
            Cell Line Information
            Publicly Available Cell Lines
             
              Other Stable Cell Lines
               
                Other Comments

                The noc and elB paralogs interact with hth to correctly specify the photoreceptors which detect polarised light at the dorsal rim of the retina, being involved in specifying both morphological and molecular fate. noc and elB also antagonise the transcriptional activator and repressor functions of oc in the retina through distinct protein domains.

                (Wernet et al., 2014)

                Loss of elB and noc activities induce extensive outgrowths, in a N-dependent way. These overgrowths are not linked to ectopic production of os.

                (Luque and Milan, 2007)

                elB appears, with noc, to regulate the growth of the highly proliferative tissue of the eye-head primordium.

                (Luque and Milan, 2007)

                Identification: screen for mutants in opsin regulation and photoreceptor cell type specification.

                (Wernet et al., 2001)

                Regulator of inner photoreceptor opsin genes.

                (Wernet et al., 2001)

                elB over-expression nearly perfectly mimics the loss-of-function phenotype of oc, one of the few mutants known to affect opsin regulation.

                (Wernet et al., 2001)

                The elbow locus is made up of two genes, elA and elB, each of which has a distinct phenotype when mutant. Mutations in elA have a strong phenotype with marked disruptions of the wing. Mutations in elB are weak, mainly affecting the alula and wing bristles. elA and elB are dominant enhancers of each other.

                (Davis et al., 1997)

                Part of the "elbow-noc" complex.

                (Lindsley and Zimm, 1992)

                Wings extended and bent backward, often warped and shortened; sometimes blistered and nicked. Alulae reduced in size with reduced number of marginal bristles -- may fuse with wing blade. Venation reduced by terminal shortening of L5 and of crossveins. Halteres reduced, often to stubs. Eye size decreased (variable, even with strong alleles). Weak alleles may overlap wild type and show only a reduction in number of marginal bristles on alulae. Some alleles may be semi-lethal when hemizygous. Class (i) alleles enhance nocSco, are semi-lethal with 35Ba alleles of noc and show a weak noc phenotype when heterozygous with strong noc alleles or noc deletions. Class (ii) alleles do not interact with these loci. All alleles more extreme when hemizygous; strong alleles nearly apterous.

                (Lindsley and Zimm, 1992)
                Relationship to Other Genes
                Source for database merge of
                Additional comments
                Nomenclature History
                Source for database identify of

                Source for identity of: elB CG4220

                (Kodira, 1999.11)

                Source for identity of: elB P10

                (Wernet, 2001.3.5)
                Nomenclature comments
                Etymology
                Synonyms and Secondary IDs (15)
                Reported As
                Symbol Synonym
                BG:DS06238.3
                (Ashburner et al., 1999, Ashburner et al., 1999.10.12)
                CG4220
                (National Institute of Genetics Fly Stocks, 2022-, Hadar et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Macdonald and Long, 2006)
                ElB
                (Dorfman et al., 2002)
                Elb
                (Tan et al., 2012)
                Elbow
                (Pereira et al., 2016)
                P10
                (Wernet et al., 2001)
                el
                (Benito-Sipos et al., 2010, Perea et al., 2009, Terriente et al., 2008, Luque and Milan, 2007, Weihe et al., 2004, Fuse et al., 1999, Lindsley and Zimm, 1992, Gubb et al., 1985, Grau et al., 1984, Ashburner et al., 1981, Ashburner et al., 1980)
                elB
                (Davis, 2003)
                elB
                (Hultmark and Andó, 2022, Hung et al., 2020, Shokri et al., 2019, Lee et al., 2018, Transgenic RNAi Project members, 2017-, Carbone et al., 2016, Gene Disruption Project members, 2016-, Shlyueva et al., 2016, Schertel et al., 2015, Gutiérrez et al., 2012, Hadar et al., 2012, Tan et al., 2012, Zhong et al., 2010, Dubruille et al., 2009, Cao et al., 2008, Engström et al., 2007, Moorman et al., 2006, Negre et al., 2006)
                elb
                (Bischof et al., 2018, Wernet et al., 2014, Weiss et al., 2010, Dorfman et al., 2001)
                elbow
                (Ghabrial et al., 2003, Glazer et al., 2000, Palsson and Gibson, 2000, Greaves et al., 1999, Fossett et al., 1994)
                Name Synonyms
                Elbow B
                (Tan et al., 2012)
                ElbowB
                (Singari et al., 2014)
                elbow
                (Wernet et al., 2014, Perea et al., 2009, Terriente et al., 2008, Luque and Milan, 2007)
                elbow B
                (Bischof et al., 2018, Singari et al., 2014, Weiss et al., 2010, Morozova et al., 2006, Negre et al., 2006)
                elbowB
                (Singari et al., 2014, Zhong et al., 2010)
                Secondary FlyBase IDs
                • FBgn0000569
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                Study result (0)
                Result
                Result Type
                Title
                External Crossreferences and Linkouts ( 47 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                FlyMine - An integrated database for Drosophila genomics
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                Flygut - An atlas of the Drosophila adult midgut
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                References (123)