Cdt1, l(2)k03308, fs(2)PA77, l(2)51Ec, fs(2)51Fa
conserved protein required for DNA replication - double-parked is sufficient to induce re-replication during development and is regulated by cyclin E/CDK2 - Double-parked must be degraded to exit S-phase, otherwise the DNA will undergo re-replication
Please see the JBrowse view of Dmel\dup for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.43
Gene model reviewed during 5.50
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dup using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\dup in JBrowse2-74
2-78.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dup is essential for endoreplication.
RNAi screen using dsRNA made from templates generated with primers directed against this gene results in the formation of compact chromatin when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
dup plays a direct role in DNA replication.
Homozygous embryos show dramatically reduced levels of DNA replication after the 15th S phase.
Gene isolated in a screen of the second chromosome identifying mutants affecting disc morphology.
Embryonic lethal alleles show increased epithelial apoptosis, incomplete cuticle formation and cessation of post-blastoderm DNA replication. Female sterile alleles result in either failure of pronuclear fusion or arrest during early mitotic divisions.
dup gene product is essential for proper DNA replication.
Mutations at the fs(2)51Fa locus cause defects in midoogenesis.
Source for merge of: dup l(2)51Ec
Source for merge of: dup l(2)k03308
Source for merge of: dup anon-WO0257455.31
Source for merge of: speckled fs(2)PA77
Source for merge of dup anon-WO0257455.31 was sequence comparison ( date:051113 ).