Gene Group: CALCIUM-ACTIVATED ION CHANNELS

General Information

Name

CALCIUM-ACTIVATED ION CHANNELS

Species

D. melanogaster

Symbol

CAACT

FlyBase ID

FBgg0001958

Date last reviewed

2024-02-29

Number of members

Description

Calcium-activated ion channels transport ions across a membrane in response to elevated calcium ion concentration.

Notes on Group

Source Material

The CALCIUM-ACTIVATED ION CHANNELS Gene Group has been compiled using the following publication(s): Attrill, 2023.11.22, Lewis, 2020, Tufi et al., 2019, Murmu and Martin, 2016, Tsai et al., 2016, Jang et al., 2015, Chintapalli et al., 2013, Stathopulos and Ikura, 2013, Wong et al., 2013, Chorna and Hasan, 2012, Murmu et al., 2010, Smyth et al., 2010, Hartzell et al., 2008, Chien and Hartzell, 2007, Gwack et al., 2007, Suzuki, 2006, Zhang et al., 2006, Galindo and Vacquier, 2005, Tavsanli et al., 2001, and Ashburner et al., 1999.10.12 .

Key Gene Ontology (GO) terms

Molecular Function

monoatomic ion-gated channel activity

Biological Process

monoatomic ion transport

Cellular Component

membrane

Related Gene Groups

Parent group(s)

ION CHANNELS BY GATING MECHANISM

Component group(s)

CALCIUM-ACTIVATED CHLORIDE CHANNEL SUBUNITS

CALCIUM LOAD-ACTIVATED CALCIUM CHANNEL SUBUNITS

CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL SUBUNITS

INTRACELLULAR CALCIUM-RELEASE CHANNEL SUBUNITS

MITOCHONDRIAL CALCIUM UNIPORTER COMPLEXES

Members (21)

For all members:

GO ribbon stack

	molecular function	biological process	cellular component

ANOCTAMINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Axs

Abnormal X segregation

(Galindo and Vacquier, 2005)

CG6938

(Galindo and Vacquier, 2005)

CG10353

(Galindo and Vacquier, 2005)

subdued

(Jang et al., 2015, Wong et al., 2013, Galindo and Vacquier, 2005)

wwk

white walker

BG:DS04929.1

(Ashburner et al., 1999.10.12)

BESTROPHINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Best1

Bestrophin 1

dbest1, best, dmBest1

(Chintapalli et al., 2013, Hartzell et al., 2008, Chien and Hartzell, 2007, Tavsanli et al., 2001)

Best2

Bestrophin 2

dbest2

(Chintapalli et al., 2013, Hartzell et al., 2008, Chien and Hartzell, 2007, Tavsanli et al., 2001)

Best3

Bestrophin 3

dbest3

(Hartzell et al., 2008, Chien and Hartzell, 2007, Tavsanli et al., 2001)

Best4

Bestrophin 4

dbest4

(Hartzell et al., 2008, Chien and Hartzell, 2007)

CALCIUM LOAD-ACTIVATED CALCIUM CHANNEL SUBUNITS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG10470

TU37B2

(Attrill, 2023.11.22)

CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL SUBUNITS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Orai

olf186-F, dOrai, ORAI1, CRACM1, l(2)k11505

(Lewis, 2020, Stathopulos and Ikura, 2013, Chorna and Hasan, 2012, Smyth et al., 2010, Gwack et al., 2007, Zhang et al., 2006)

Stim

Stromal interaction molecule

dSTIM, STIM1, D-Stim

(Lewis, 2020, Stathopulos and Ikura, 2013, Chorna and Hasan, 2012, Smyth et al., 2010, Gwack et al., 2007, Zhang et al., 2006)

INTRACELLULAR CALCIUM-RELEASE CHANNEL SUBUNITS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Itpr

Inositol 1,4,5,-trisphosphate receptor

Itp-r83A, IP3R, IP₃R, InsP₃R, IP3 receptor

(Murmu and Martin, 2016, Murmu et al., 2010)

RyR

Ryanodine receptor

Rya-r44F, Ryanodine receptor 44F, l(2)k04913, DRR, dry

(Murmu and Martin, 2016, Murmu et al., 2010)

MITOCHONDRIAL CALCIUM UNIPORTER COMPLEX

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

EMRE

Essential MCU regulator

(Tufi et al., 2019, Tsai et al., 2016)

MCU

Mitochondrial calcium uniporter

(Tufi et al., 2019, Tsai et al., 2016)

MICU1

Mitochondrial calcium uptake 1

(Tufi et al., 2019, Tsai et al., 2016)

MICU3

Mitochondrial calcium uptake 3

(Tufi et al., 2019)

MITOCHONDRIAL CALCIUM UNIPORTER COMPLEX - CG4704 VARIANT

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG4704

(FlyBase, 2024-)

EMRE

Essential MCU regulator

(Tufi et al., 2019, Tsai et al., 2016)

MCU

Mitochondrial calcium uniporter

(Tufi et al., 2019, Tsai et al., 2016)

MICU3

Mitochondrial calcium uptake 3

(Tufi et al., 2019)

TWEETY FAMILY

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG3638

EG:33C11.3, BG00376

(Suzuki, 2006)

tty

tweety

(Chintapalli et al., 2013, Suzuki, 2006)

External Data

Equivalent Group(s)

Other resource(s)

Synonyms and Secondary IDs

Synonym(s)

CAACT

CALCIUM-ACTIVATED ION CHANNELS

Calcium ion regulated ion channels

Secondary FlyBase ID(s)

References (22)

Report Sections

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