FB2024_03 , released June 25, 2024
Gene Group - Macromolecular Complex: POLYCOMB REPRESSIVE COMPLEX 1, SU(Z)2 VARIANT
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General Information
Name
POLYCOMB REPRESSIVE COMPLEX 1, SU(Z)2 VARIANT
Species
D. melanogaster
Symbol
PRC1-VAR
FlyBase ID
FBgg0001860
Date last reviewed
2023-08-08
Number of members
5
Description
Description
The Polycomb repressive complex 1 (PRC1) is a Polycomb group complex. It binds to histone H3K27me3 (histone H3 K27 methylation is catalyzed by PRC2) and monoubiquitinates H2A on K119. This leads to chromatin compaction, RNA polymerase II stalling and gene silencing. (Adapted from FBrf0179742 and FBrf0228921).
Notes on Group
Source Material
The POLYCOMB REPRESSIVE COMPLEX 1, SU(Z)2 VARIANT Gene Group has been compiled using the following publication(s): Grossniklaus and Paro, 2014 and Lo et al., 2009 .
Key Gene Ontology (GO) terms
Molecular Function
histone H2AK119 ubiquitin ligase activity
Biological Process
heterochromatin formation
Cellular Component
PRC1 complex
Related Gene Groups
Parent group(s)
CHROMATIN MODIFYING COMPLEXES
POLYCOMB GROUP COMPLEXES
Members (5)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Pc
Polycomb
PcG, Pc-G
(Lo et al., 2009)
ph-d
polyhomeotic distal
ph, Polyhomeotic, DROZFP, EG:BACN25G24.3, PHD
(Grossniklaus and Paro, 2014)
ph-p
polyhomeotic proximal
ph, Polyhomeotic, PHP, EG:87B1.5, ph-proximal
(Lo et al., 2009)
Sce
Sex combs extra
dRING, dRING1, Ring, Sex comb extra, RING1
(Lo et al., 2009)
Su(z)2
Suppressor of zeste 2
Suppressor 2 of zeste, Arp, Su(z)2D, Su(z)3, Suppressor of zeste two
(Lo et al., 2009)
External Data
Synonyms and Secondary IDs
Synonym(s)
PRC1-VAR
POLYCOMB REPRESSIVE COMPLEX 1, SU(Z)2 VARIANT
Secondary FlyBase ID(s)
References (3)