FB2024_02 , released April 23, 2024
Gene Group: POLYCOMB GROUP COMPLEXES
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General Information
Name
POLYCOMB GROUP COMPLEXES
Species
D. melanogaster
Symbol
PCG-C
FlyBase ID
FBgg0000309
Date last reviewed
2017-10-10
Number of members
19
Description
Description
The Polycomb group (PcG) proteins are epigenetic regulators, best characterized for the repression of Hox gene expression. PcG proteins form complexes that regulate chromatin structure. (Adapted from FBrf0220020 and FBrf0228921).
Notes on Group
Source Material
The POLYCOMB GROUP COMPLEXES Gene Group has been compiled using the following publication(s): Fischer et al., 2022, Kassis et al., 2017, Piunti and Shilatifard, 2016, Grossniklaus and Paro, 2014, Lanzuolo and Orlando, 2012, Margueron and Reinberg, 2011, Scheuermann et al., 2010, Lo et al., 2009, Lagarou et al., 2008, and Klymenko et al., 2006 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
heterochromatin formation
Cellular Component
PcG protein complex
Related Gene Groups
Component group(s)
dRING-ASSOCIATED FACTORS
PHO REPRESSIVE COMPLEX - PHOL VARIANT
PHO REPRESSIVE COMPLEX - PHO VARIANT
POLYCOMB REPRESSIVE COMPLEX 1, PSC VARIANT
POLYCOMB REPRESSIVE COMPLEX 1, SU(Z)2 VARIANT
POLYCOMB REPRESSIVE COMPLEX 2, JARID2-JING VARIANT
POLYCOMB REPRESSIVE COMPLEX 2, PCL VARIANT
POLYCOMB REPRESSIVE DEUBIQUITINASE COMPLEX
Other related group(s)
HOX GENE COMPLEX
POLYCOMB GROUP RECRUITERS/DNA-BINDING PROTEINS
TRITHORAX GROUP COMPLEXES
Members (19)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
dRING-ASSOCIATED FACTORS
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Kdm2
Lysine demethylase 2
dKDM2, JHDM1, Lysine (K)-specific demethylase 2
(Kassis et al., 2017, Lanzuolo and Orlando, 2012, Lagarou et al., 2008)
Psc
Posterior sex combs
Posterior sex comb, l(2)49Ea
(Kassis et al., 2017, Lanzuolo and Orlando, 2012, Lagarou et al., 2008)
Sce
Sex combs extra
dRING, dRING1, Ring, Sex comb extra, RING1
(Kassis et al., 2017, Lanzuolo and Orlando, 2012, Lagarou et al., 2008)
PHO REPRESSIVE COMPLEX - PHOL VARIANT
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
phol
pleiohomeotic like
pho-like
(Kassis et al., 2017, Klymenko et al., 2006)
Sfmbt
Scm-related gene containing four mbt domains
dSfmbt
(Kassis et al., 2017, Klymenko et al., 2006)
PHO REPRESSIVE COMPLEX - PHO VARIANT
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
pho
pleiohomeotic
l(4)29, YY1, l(4)BU-2, l(4)102EFc, Pleohomeotic
(Kassis et al., 2017, Lanzuolo and Orlando, 2012, Klymenko et al., 2006)
Sfmbt
Scm-related gene containing four mbt domains
dSfmbt
(Kassis et al., 2017, Lanzuolo and Orlando, 2012, Klymenko et al., 2006)
POLYCOMB REPRESSIVE COMPLEX 1, PSC VARIANT
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Pc
Polycomb
PcG, Pc-G
(Piunti and Shilatifard, 2016, Grossniklaus and Paro, 2014, Lanzuolo and Orlando, 2012)
ph-d
polyhomeotic distal
ph, Polyhomeotic, DROZFP, EG:BACN25G24.3, PHD
(Piunti and Shilatifard, 2016, Grossniklaus and Paro, 2014, Lanzuolo and Orlando, 2012)
ph-p
polyhomeotic proximal
ph, Polyhomeotic, PHP, ph-proximal, EG:87B1.5
(Piunti and Shilatifard, 2016, Grossniklaus and Paro, 2014, Lanzuolo and Orlando, 2012)
Psc
Posterior sex combs
Posterior sex comb, l(2)49Ea
(Piunti and Shilatifard, 2016, Grossniklaus and Paro, 2014, Lanzuolo and Orlando, 2012)
Sce
Sex combs extra
dRING, dRING1, Ring, Sex comb extra, RING1
(Piunti and Shilatifard, 2016, Grossniklaus and Paro, 2014, Lanzuolo and Orlando, 2012)
POLYCOMB REPRESSIVE COMPLEX 1, SU(Z)2 VARIANT
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Pc
Polycomb
PcG, Pc-G
(Lo et al., 2009)
ph-d
polyhomeotic distal
ph, Polyhomeotic, DROZFP, EG:BACN25G24.3, PHD
(Grossniklaus and Paro, 2014)
ph-p
polyhomeotic proximal
ph, Polyhomeotic, PHP, ph-proximal, EG:87B1.5
(Lo et al., 2009)
Sce
Sex combs extra
dRING, dRING1, Ring, Sex comb extra, RING1
(Lo et al., 2009)
Su(z)2
Suppressor of zeste 2
Suppressor 2 of zeste, Arp, Su(z)2D, Su(z)3, l(2)k06344
(Lo et al., 2009)
POLYCOMB REPRESSIVE COMPLEX 2, JARID2-JING VARIANT
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Caf1-55
Chromatin assembly factor 1, p55 subunit
p55, Caf1, NURF, NURF55, NURF-55
(Fischer et al., 2022)
E(z)
Enhancer of zeste
EZ, pco, l(3)1902, Su(z)301, polycombeotic
(Fischer et al., 2022)
esc
extra sexcombs
(Fischer et al., 2022)
Jarid2
Jumonji, AT rich interactive domain 2
l(3)j2B8, dJmj
(Fischer et al., 2022)
jing
jing
1.28, l(2)01094, rhumba, l(2)22F3
(Fischer et al., 2022)
Su(z)12
Su(z)12
Suppressor of zeste 12, l(3)76BDo, SUZ12
(Fischer et al., 2022)
POLYCOMB REPRESSIVE COMPLEX 2, PCL VARIANT
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Caf1-55
Chromatin assembly factor 1, p55 subunit
p55, Caf1, NURF, NURF55, NURF-55
(Fischer et al., 2022, Piunti and Shilatifard, 2016, Lanzuolo and Orlando, 2012, Margueron and Reinberg, 2011)
E(z)
Enhancer of zeste
EZ, pco, l(3)1902, Su(z)301, polycombeotic
(Fischer et al., 2022, Kassis et al., 2017, Piunti and Shilatifard, 2016, Lanzuolo and Orlando, 2012, Margueron and Reinberg, 2011)
esc
extra sexcombs
(Fischer et al., 2022, Kassis et al., 2017, Piunti and Shilatifard, 2016, Lanzuolo and Orlando, 2012, Margueron and Reinberg, 2011)
Pcl
Polycomblike
l(2)s1859
(Fischer et al., 2022)
Su(z)12
Su(z)12
Suppressor of zeste 12, l(3)76BDo, SUZ12
(Fischer et al., 2022, Kassis et al., 2017, Piunti and Shilatifard, 2016, Lanzuolo and Orlando, 2012, Margueron and Reinberg, 2011)
POLYCOMB REPRESSIVE DEUBIQUITINASE COMPLEX
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Asx
Additional sex combs
xenicid, xen
(Kassis et al., 2017, Lanzuolo and Orlando, 2012, Scheuermann et al., 2010)
caly
calypso
(Kassis et al., 2017, Lanzuolo and Orlando, 2012, Scheuermann et al., 2010)
External Data
Equivalent Group(s)
Other resource(s)

[The Polycomb and Trithorax page, Cavalli lab](http://www.igh.cnrs.fr/equip/cavalli/link.PolycombTeaching.html)

Synonyms and Secondary IDs
Synonym(s)
PCG-C
POLYCOMB GROUP COMPLEXES
Polycomb complexes
PcG
PRC
Secondary FlyBase ID(s)
References (11)