RNA polymerase III (RNAP III) synthesizes short, non-coding RNAs including tRNAs, the small 5S rRNA and the U6 snRNA. It comprises 17 subunits, ten of which form a structurally conserved catalytic core with additional subunits located on the periphery. Notably, five RNAP III subunits are shared among all three RNAPs and two others are shared between RNAPs I and III. (Adapted from
FBrf0247389.)