FB2024_03 , released June 25, 2024
Gene Group: RNA POLYMERASE CATALYTIC SUBUNITS
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General Information
Name
RNA POLYMERASE CATALYTIC SUBUNITS
Species
D. melanogaster
Symbol
RNAPOL-C
FlyBase ID
FBgg0001250
Date last reviewed
2021-01-04
Number of members
20
Description
Description
DNA-directed RNA polymerases (RNAPs) catalyze the synthesis of RNA from DNA templates. Nuclear DNA is transcribed by three different multi-subunit polymerases, RNAPs I, II and III, which synthesize mRNAs, rRNAs, tRNAs and other non-coding RNAs. Although composed of between 12-17 subunits, all three nuclear RNAPs contain a ten-subunit catalytic core. Mitochondrial RNA is synthesized by a single subunit RNA polymerase. DNA primases are a class of RNA polymerases that catalyse the synthesis of short RNA primers that are extended by DNA polymerases during DNA replication. (Adapted from PMID:22365827 and PMID:19540940.)
Notes on Group

The 'RNA polymerase catalytic subunits' group contains the core RNAP subunits defined in PMID:22365827, together with the DNA primase catalytic subunit and the single subunit mitochondrial RNAP.

Source Material
The RNA POLYMERASE CATALYTIC SUBUNITS Gene Group has been compiled using the following publication(s): Marygold et al., 2020 .
Key Gene Ontology (GO) terms
Molecular Function
DNA-directed 5'-3' RNA polymerase activity
Biological Process
RNA biosynthetic process
Cellular Component
Enzymatic activity
Enzyme name (EC)
DNA-directed RNA polymerase (2.7.7.6)
Related Gene Groups
Parent group(s)
NUCLEOTIDYLTRANSFERASES
Other related group(s)
RNA POLYMERASES
Members (20)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Polr1A
RNA polymerase I subunit A
RpI1, RNA polymerase I, RPA1, RNA polymerase I subunit, Rpl1
(FlyBase, 2017-)
Polr1B
RNA polymerase I subunit B
RpI135, Rpl135, DmRP135, RNA polymerase I
(FlyBase, 2017-)
Polr1C
RNA polymerase I and III subunit C
(FlyBase, 2017-)
Polr1D
RNA polymerase I and III subunit D
l(2)37Cg, Cg
(FlyBase, 2017-)
Polr1H
RNA polymerase I subunit H
RpI12
(FlyBase, 2017-)
Polr2A
RNA polymerase II subunit A
RNA polymerase II, RpII215, Pol II, RNAPII, PolII
(FlyBase, 2017-)
Polr2B
RNA polymerase II subunit B
RNA polymerase II, RpII140, DmRP140, wimp, PolII
(FlyBase, 2017-)
Polr2C
RNA polymerase II subunit C
Rpb3, RNA polymerase II, RpII33, l(2)34Dg, Pol II
(FlyBase, 2017-)
Polr2E
RNA polymerase II, I and III subunit E
Rpb5, DmRPB5
(FlyBase, 2017-)
Polr2F
RNA polymerase II, I and III subunit F
RNA polymerase II, Pol II, RpII18, PolII, RNAP II
(FlyBase, 2017-)
Polr2H
RNA polymerase II, I and III subunit H
Rpb8
(FlyBase, 2017-)
Polr2I
RNA polymerase II subunit I
RNA polymerase II, RpII15, PolII, Pol II, RNAP II
(FlyBase, 2017-)
Polr2J
RNA polymerase II subunit J
Rpb11
(FlyBase, 2017-)
Polr2K
RNA polymerase II, I and III subunit K
Rpb12
(FlyBase, 2017-)
Polr2L
RNA polymerase II, I and III subunit L
Rpb10
(FlyBase, 2017-)
Polr3A
RNA polymerase III subunit A
dC160
(FlyBase, 2017-)
Polr3B
RNA polymerase III subunit B
RpIII128, DmRP128, RNA polymerase III, RP128
(FlyBase, 2017-)
Polr3K
RNA polymerase III subunit K
(FlyBase, 2017-)
PolrMT
RNA polymerase mitochondrial
mtRNApol, mitochondrial RNA polymerase
(FlyBase, 2017-)
Prim1
DNA primase subunit 1
DNApol-α50, DNA polymerase α, DNApol-alpha50, Dpri50, pol α
(Marygold et al., 2020, FlyBase, 2017-)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
RNAPOL-C
RNA POLYMERASES
RNA POLYMERASE CATALYTIC SUBUNITS
RNA POLYMERASE CATALYTIC CORE SUBUNITS
Secondary FlyBase ID(s)
References (3)