FB2024_03 , released June 25, 2024
Gene Group - Macromolecular Complex: RNA POLYMERASE I
Open Close
General Information
Name
RNA POLYMERASE I
Species
D. melanogaster
Symbol
RNAPI
FlyBase ID
FBgg0001647
Date last reviewed
2023-08-08
Number of members
13
Description
Description
RNA polymerase I (RNAP I) synthesizes the ribosomal RNA precursor that is processed into most ribosomal RNAs (rRNAs). It comprises 12-14 subunits (12 in D. melanogaster), ten of which form a structurally conserved catalytic core with additional subunits located on the periphery. Notably, five RNAP I subunits are shared with the other two nuclear RNAPs, and two others are shared between RNAPs I and III. (Adapted from FBrf0247389.)
Notes on Group

D. melanogaster lacks an identifiable ortholog of RNAP I subunits RPA14 (yeast) and RPA34 (yeast)/POLR1G (human) (FBrf0244832, FBrf0247389).

Source Material
The RNA POLYMERASE I Gene Group has been compiled using the following publication(s): Palumbo and Knutson, 2024 and Marygold et al., 2020 .
Key Gene Ontology (GO) terms
Molecular Function
RNA polymerase I activity
Biological Process
transcription by RNA polymerase I
Cellular Component
RNA polymerase I complex
Related Gene Groups
Parent group(s)
RNA POLYMERASES
Other related group(s)
RNA POLYMERASE CATALYTIC SUBUNITS
Members (13)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Polr1A
RNA polymerase I subunit A
RpI1, RNA polymerase I, RPA1, RNA polymerase I subunit, Rpl1
(Marygold et al., 2020)
Polr1B
RNA polymerase I subunit B
RpI135, Rpl135, DmRP135, RNA polymerase I
(Marygold et al., 2020)
Polr1C
RNA polymerase I and III subunit C
(Marygold et al., 2020)
Polr1D
RNA polymerase I and III subunit D
l(2)37Cg, Cg
(Marygold et al., 2020)
Polr1E
RNA polymerase I subunit E
(Marygold et al., 2020)
Polr1F
RNA polymerase I subunit F
BEST:GH23590
(Marygold et al., 2020)
Polr1G
RNA polymerase I subunit G
(Palumbo and Knutson, 2024)
Polr1H
RNA polymerase I subunit H
RpI12
(Marygold et al., 2020)
Polr2E
RNA polymerase II, I and III subunit E
Rpb5, DmRPB5
(Marygold et al., 2020)
Polr2F
RNA polymerase II, I and III subunit F
RNA polymerase II, Pol II, RpII18, PolII, RNAP II
(Marygold et al., 2020)
Polr2H
RNA polymerase II, I and III subunit H
Rpb8
(Marygold et al., 2020)
Polr2K
RNA polymerase II, I and III subunit K
Rpb12
(Marygold et al., 2020)
Polr2L
RNA polymerase II, I and III subunit L
Rpb10
(Marygold et al., 2020)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
RNAPI
RNA POLYMERASE I
Secondary FlyBase ID(s)
References (3)