FB2024_02 , released April 23, 2024
Gene Group: RNA POLYMERASES
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General Information
Name
RNA POLYMERASES
Species
D. melanogaster
Symbol
RNAP
FlyBase ID
FBgg0001646
Date last reviewed
2021-01-04
Number of members
32
Description
Description
Three highly conserved, multisubunit RNA polymerase (RNAP) enzymes, RNAPs I, II, and III, transcribe the eukaryotic nuclear genome. Each one synthesizes different classes of RNA from DNA templates: RNAP I synthesizes the ribosomal RNA precursor that is processed into most ribosomal RNAs (rRNAs), RNAP II makes messenger RNAs (mRNAs) and a variety of non-coding RNAs, and RNAP III synthesizes short, non-coding RNAs including transfer RNAs (tRNAs), the small 5S rRNA and the U6 small nuclear RNA. Each RNAP contains between 12-17 subunits, ten of which form a structurally conserved catalytic core with additional subunits located on the periphery. Notably, five subunits are shared among all three RNAPs and two others are shared between RNAPs I and III. In contrast to the nuclear RNAPs, a single subunit mitochondrial RNAP transcribes the rRNAs, mRNAs and tRNAs of the mitochondrial genome. (Adapted from FBrf0247389.)
Notes on Group
Source Material
The RNA POLYMERASES Gene Group has been compiled using the following publication(s): Palumbo and Knutson, 2024, Marygold et al., 2020, Jishage et al., 2018, and Aoyagi and Wassarman, 2000 .
Key Gene Ontology (GO) terms
Molecular Function
DNA-directed 5'-3' RNA polymerase activity
Biological Process
DNA-templated transcription
Cellular Component
DNA-directed RNA polymerase complex
Enzymatic activity
Enzyme name (EC)
DNA-directed RNA polymerase (2.7.7.6)
Related Gene Groups
Component group(s)
MITOCHONDRIAL RNA POLYMERASES
RNA POLYMERASE I
RNA POLYMERASE II
RNA POLYMERASE III
Other related group(s)
RNA POLYMERASE CATALYTIC SUBUNITS
Members (32)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
MITOCHONDRIAL RNA POLYMERASES
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
PolrMT
RNA polymerase mitochondrial
mtRNApol, mitochondrial RNA polymerase
(Marygold et al., 2020, FlyBase, 2017-)
RNA POLYMERASE I
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Polr1A
RNA polymerase I subunit A
RpI1, Rpl1, RNA polymerase I subunit, RPA1, RNA polymerase I
(Marygold et al., 2020)
Polr1B
RNA polymerase I subunit B
RpI135, DmRP135, Rpl135, RNA polymerase I
(Marygold et al., 2020)
Polr1C
RNA polymerase I and III subunit C
(Marygold et al., 2020)
Polr1D
RNA polymerase I and III subunit D
l(2)37Cg, Cg
(Marygold et al., 2020)
Polr1E
RNA polymerase I subunit E
(Marygold et al., 2020)
Polr1F
RNA polymerase I subunit F
BEST:GH23590
(Marygold et al., 2020)
Polr1G
RNA polymerase I subunit G
(Palumbo and Knutson, 2024)
Polr1H
RNA polymerase I subunit H
RpI12
(Marygold et al., 2020)
Polr2E
RNA polymerase II, I and III subunit E
Rpb5, DmRPB5
(Marygold et al., 2020)
Polr2F
RNA polymerase II, I and III subunit F
RNA polymerase II, Pol II, RpII18, PolII, RNAP II
(Marygold et al., 2020)
Polr2H
RNA polymerase II, I and III subunit H
Rpb8
(Marygold et al., 2020)
Polr2K
RNA polymerase II, I and III subunit K
Rpb12
(Marygold et al., 2020)
Polr2L
RNA polymerase II, I and III subunit L
Rpb10
(Marygold et al., 2020)
RNA POLYMERASE II
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Polr2A
RNA polymerase II subunit A
RNA polymerase II, Pol II, RpII215, RNAPII, PolII
(Marygold et al., 2020, Aoyagi and Wassarman, 2000)
Polr2B
RNA polymerase II subunit B
RNA polymerase II, RpII140, DmRP140, wimp, Pol II
(Marygold et al., 2020, Aoyagi and Wassarman, 2000)
Polr2C
RNA polymerase II subunit C
Rpb3, RNA polymerase II, RpII33, l(2)34Dg, Pol II
(Marygold et al., 2020, Aoyagi and Wassarman, 2000)
Polr2D
RNA polymerase II subunit D
Rpb4, DmRPB4
(Marygold et al., 2020, Aoyagi and Wassarman, 2000)
Polr2E
RNA polymerase II, I and III subunit E
Rpb5, DmRPB5
(Marygold et al., 2020, Aoyagi and Wassarman, 2000)
Polr2F
RNA polymerase II, I and III subunit F
RNA polymerase II, Pol II, RpII18, PolII, RNAP II
(Marygold et al., 2020, Aoyagi and Wassarman, 2000)
Polr2G
RNA polymerase II subunit G
Rpb7
(Marygold et al., 2020, Aoyagi and Wassarman, 2000)
Polr2H
RNA polymerase II, I and III subunit H
Rpb8
(Marygold et al., 2020, Aoyagi and Wassarman, 2000)
Polr2I
RNA polymerase II subunit I
RNA polymerase II, RpII15, PolII, Pol II, RNA Pol II
(Marygold et al., 2020, Aoyagi and Wassarman, 2000)
Polr2J
RNA polymerase II subunit J
Rpb11
(Marygold et al., 2020, Aoyagi and Wassarman, 2000)
Polr2K
RNA polymerase II, I and III subunit K
Rpb12
(Marygold et al., 2020, Aoyagi and Wassarman, 2000)
Polr2L
RNA polymerase II, I and III subunit L
Rpb10
(Marygold et al., 2020, Aoyagi and Wassarman, 2000)
Polr2M
RNA polymerase II subunit M
Gdown1, Gdn1
(Marygold et al., 2020, Jishage et al., 2018)
RNA POLYMERASE III
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Polr1C
RNA polymerase I and III subunit C
(Marygold et al., 2020)
Polr1D
RNA polymerase I and III subunit D
l(2)37Cg, Cg
(Marygold et al., 2020)
Polr2E
RNA polymerase II, I and III subunit E
Rpb5, DmRPB5
(Marygold et al., 2020)
Polr2F
RNA polymerase II, I and III subunit F
RNA polymerase II, Pol II, RpII18, PolII, RNAP II
(Marygold et al., 2020)
Polr2H
RNA polymerase II, I and III subunit H
Rpb8
(Marygold et al., 2020)
Polr2K
RNA polymerase II, I and III subunit K
Rpb12
(Marygold et al., 2020)
Polr2L
RNA polymerase II, I and III subunit L
Rpb10
(Marygold et al., 2020)
Polr3A
RNA polymerase III subunit A
dC160
(Marygold et al., 2020)
Polr3B
RNA polymerase III subunit B
RpIII128, DmRP128, RP128, RNA polymerase III
(Marygold et al., 2020)
Polr3C
RNA polymerase III subunit C
(Marygold et al., 2020)
Polr3D
RNA polymerase III subunit D
(Marygold et al., 2020)
Polr3E
RNA polymerase III subunit E
Sin
(Marygold et al., 2020)
Polr3F
RNA polymerase III subunit F
(Marygold et al., 2020)
Polr3G
RNA polymerase III subunit G
(Marygold et al., 2020)
Polr3H
RNA polymerase III subunit H
lincRNA.S4825
(Marygold et al., 2020)
Polr3I
RNA polymerase III subunit I
Rcp
(Marygold et al., 2020)
Polr3K
RNA polymerase III subunit K
(Marygold et al., 2020)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
RNAP
RNA POLYMERASES
Secondary FlyBase ID(s)
References (6)