FB2024_03 , released June 25, 2024
Gene Group: GAMMA-GLUTAMYL HYDROLASES
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General Information
Name
GAMMA-GLUTAMYL HYDROLASES
Species
D. melanogaster
Symbol
GGH
FlyBase ID
FBgg0001408
Date last reviewed
2020-06-08
Number of members
2
Description
Description
Gamma-glutamyl hydrolases belong to MEROPS family C26. They are lysosomal and secreted cysteine peptidases that cleave gamma-linked glutamate bonds in substrates such as antifolate and folate polyglutamates. (Adapted from PMID: 10739875.)
Notes on Group
Source Material
The GAMMA-GLUTAMYL HYDROLASES Gene Group has been compiled using the following publication(s): Rawlings and Barrett, 1996- .
Key Gene Ontology (GO) terms
Molecular Function
gamma-glutamyl-peptidase activity
Biological Process
proteolysis
Cellular Component
lysosome
Enzymatic activity
Enzyme name (EC)
folate gamma-glutamyl hydrolase (3.4.19.9)
Related Gene Groups
Parent group(s)
CYSTEINE PEPTIDASES
PEPTIDASE FAMILY C26
Members (2)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
l(3)72Dp
lethal (3) 72Dp
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
l(3)72Dr
lethal (3) 72Dr
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
External Data
Equivalent Group(s)
Other resource(s)

[MEROPS Family C26](https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=c26)

Synonyms and Secondary IDs
Synonym(s)
GGH
GAMMA-GLUTAMYL HYDROLASES
Secondary FlyBase ID(s)
References (3)