FB2024_03 , released June 25, 2024
Gene Group - Macromolecular Complex: HEDGEHOG SIGNALING COMPLEX
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General Information
Name
HEDGEHOG SIGNALING COMPLEX
Species
D. melanogaster
Symbol
HSC
FlyBase ID
FBgg0001342
Date last reviewed
2023-08-08
Number of members
3
Description
Description
The Hedgehog signaling complex (HSC) is involved in hedgehog signaling pathway. In the absence of hh, HSC promotes the proteolytic processing of the transcription factor and HSC component ci to its repressor form. hh activation of the pathway blocks the processing of ci, allowing the accumulation of the full-length activator protein. (Adapted from FBrf0174381.)
Notes on Group

In the absence of hh stimulation, Hedgehog signaling complex (HSC) has been shown to associate with microtubules (FBrf0096169). A non microtubule associated, Su(fu)-containing tetrameric HSC has also been described (FBrf0128807).

Source Material
The HEDGEHOG SIGNALING COMPLEX Gene Group has been compiled using the following publication(s): Ogden et al., 2004, Stegman et al., 2000, and Robbins et al., 1997 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
Cellular Component
Hedgehog signaling complex
Related Gene Groups
Other related group(s)
Hedgehog Signaling Pathway
Members (3)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
ci
cubitus interruptus
l(4)17, ciD, CID, Gli, l(4)13
(Ogden et al., 2004, Stegman et al., 2000, Robbins et al., 1997)
cos
costa
Cos2, Costal2, cos-2, Costal-2, Costal 2
(Ogden et al., 2004, Stegman et al., 2000, Robbins et al., 1997)
fu
fused
(Ogden et al., 2004, Stegman et al., 2000, Robbins et al., 1997)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
HSC
HEDGEHOG SIGNALING COMPLEX
Secondary FlyBase ID(s)
References (4)