FB2024_03 , released June 25, 2024
Gene Group - Macromolecular Complex: DNA POLYMERASE EPSILON
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General Information
Name
DNA POLYMERASE EPSILON
Species
D. melanogaster
Symbol
DNAPOLE
FlyBase ID
FBgg0001210
Date last reviewed
Number of members
4
Description
Description
DNA polymerase epsilon functions as a leading strand polymerase during nuclear DNA synthesis. It is a heterotetramer in which DNApol-ε255 encodes the catalytic subunit with polymerase and 3'-5' exonuclease proofreading activities. (Adapted from PMID:30005324.)
Notes on Group
Source Material
The DNA POLYMERASE EPSILON Gene Group has been compiled using the following publication(s): Marygold et al., 2020 .
Key Gene Ontology (GO) terms
Molecular Function
DNA-directed DNA polymerase activity
3'-5'-DNA exonuclease activity
Biological Process
leading strand elongation
DNA replication proofreading
Cellular Component
epsilon DNA polymerase complex
nucleus
Enzymatic activity
Enzyme name (EC)
DNA-directed DNA polymerase (2.7.7.7)
Related Gene Groups
Parent group(s)
DNA POLYMERASES
Members (4)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Chrac-14
Chromatin accessibility complex 14kD protein
CHRAC14, PolE3, CHRAC, mary
(Marygold et al., 2020, FlyBase, 2017-)
PolE1
DNA polymerase epsilon subunit 1
DNApol-epsilon, DNApol-ε, DNApol-ε255, DNA polymerase ε, Polε
(Marygold et al., 2020, FlyBase, 2017-)
PolE2
DNA polymerase epsilon subunit 2
DNApol-ε58
(Marygold et al., 2020, FlyBase, 2017-)
PolE4
DNA polymerase epsilon subunit 4
Mes4, NF-Yc
(Marygold et al., 2020, FlyBase, 2017-)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
DNAPOLE
DNA POLYMERASE EPSILON
Secondary FlyBase ID(s)
References (3)