Gene Group: METHYLTRANSFERASES

General Information

Name

METHYLTRANSFERASES

Species

D. melanogaster

Symbol

METH

FlyBase ID

FBgg0001159

Date last reviewed

2019-04-15

Number of members

127

Description

Methyltransferases catalyze the addition of one or more methyl groups to substrates like protein, DNA, RNA and small molecules. (Adapted from PMID:26652298).

Notes on Group

Source Material

The METHYLTRANSFERASES Gene Group has been compiled using the following publication(s): Jiang et al., 2017, Haussmann et al., 2016, Calpena et al., 2015, Wang et al., 2015, Shilatifard, 2012, Villar-Garea et al., 2012, Wang and Li, 2012, Mohan et al., 2011, Schaefer et al., 2010, Thompson and Travers, 2008, Mis et al., 2006, Dillon et al., 2005, Boulanger et al., 2004, and Schotta et al., 2004 .

Key Gene Ontology (GO) terms

Molecular Function

methyltransferase activity

Biological Process

Cellular Component

Enzymatic activity

Enzyme name (EC)

2.1.1.-

Related Gene Groups

Parent group(s)

ONE-CARBON GROUP TRANSFERASES

Component group(s)

DNA METHYLTRANSFERASES

PROTEIN METHYLTRANSFERASES

RNA METHYLTRANSFERASES

UNCLASSIFIED METHYLTRANSFERASES

Members (127)

For all members:

GO ribbon stack

	molecular function	biological process	cellular component

DNA METHYLTRANSFERASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Mt2

Methyltransferase 2

Dnmt2, dDnmt2, DNMT, DNA methyltransferase 2

(FlyBase, 2017-, Schaefer et al., 2010)

MRNA METHYLTRANSFERASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

aft

adrift

(FlyBase, 2017-)

Cmtr1

Cap methyltransferase 1

(FlyBase, 2017-)

Mettl3

Methyltransferase like 3

Ime4, Inducer of meiosis 4

(FlyBase, 2017-, Haussmann et al., 2016)

Rnmt

RNA guanine-7 methyltransferase

l(2)br9, l(2)35Bd, br9, BG:DS00929.5

(FlyBase, 2017-)

PROTEIN ARGININE N-METHYLTRANSFERASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Art1

Arginine methyltransferase 1

DART1, PRMT1

(Wang et al., 2015, Wang and Li, 2012, Boulanger et al., 2004)

Art2

Arginine methyltransferase 2

DART2

(Wang et al., 2015, Boulanger et al., 2004)

Art3

Arginine methyltransferase 3

DART3

(Wang et al., 2015, Wang and Li, 2012, Boulanger et al., 2004)

Art4

Arginine methyltransferase 4

DART4, Carmer

(Wang et al., 2015, Wang and Li, 2012, Boulanger et al., 2004)

Art6

Arginine methyltransferase 6

DART6

(Wang et al., 2015, Boulanger et al., 2004)

Art7

Arginine methyltransferase 7

DART7

(Wang et al., 2015, Wang and Li, 2012, Boulanger et al., 2004)

Art8

Arginine methyltransferase 8

DART8

(Wang et al., 2015, Villar-Garea et al., 2012, Boulanger et al., 2004)

Art9

Arginine methyltransferase 9

DART9

(Wang et al., 2015, Boulanger et al., 2004)

CG17726

(FlyBase, 2017-)

CG32152

(FlyBase, 2017-)

csul

capsuleen

dart5, dPRMT5, JBP1, PRMT5

(Wang et al., 2015, Wang and Li, 2012, Boulanger et al., 2004)

PROTEIN CARBOXYL O-METHYLTRANSFERASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG3793

BG:DS09217.4

(FlyBase, 2017-)

Icmt

Isoprenylcysteine carboxyl methyltransferase

ste14, Dmel\Ste14

(FlyBase, 2017-)

Pcmt

Protein-L-isoaspartate (D-aspartate) O-methyltransferase

Pimt

(FlyBase, 2017-)

PROTEIN-GLUTAMINE N-METHYLTRANSFERASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG10909

(FlyBase, 2017-)

Fib

Fibrillarin

(FlyBase, 2017-)

RRNA METHYLTRANSFERASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

Fibrillarin

(FlyBase, 2017-)

l(2)10685

lethal (2) 10685

(FlyBase, 2017-)

Mettl5

Methyltransferase like 5

(FlyBase, 2017-)

Mrm2

Mitochondrial rRNA methyltransferase 2

(FlyBase, 2017-)

mtTFB1

Mitochondrial Transcription Factor B1

d-mtTFB1

(FlyBase, 2017-)

mtTFB2

mitochondrial transcription factor B2

d-mtTFB2, TFB2

(FlyBase, 2017-)

Nsun5

Nop2/Sun-like domain containing protein 5

(FlyBase, 2017-)

SET AND MYND DOMAIN FAMILY

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Smyd3

SET and MYND domain containing, class 3

EG:BACR7C10.4, Bzd, Buzidau

(Calpena et al., 2015)

Smyd4-1

SET and MYND domain containing, class 4, member 1

(Jiang et al., 2017, Calpena et al., 2015, Thompson and Travers, 2008, Schotta et al., 2004)

Smyd4-2

SET and MYND domain containing, class 4, member 2

Smyd4, dSmyd4

(Jiang et al., 2017, Calpena et al., 2015, Thompson and Travers, 2008)

Smyd4-3

SET and MYND domain containing, class 4, member 3

(Jiang et al., 2017, Calpena et al., 2015, Thompson and Travers, 2008)

Smyd4-4

SET and MYND domain containing, class 4, member 4

BcDNA:LD29892

(Jiang et al., 2017, Calpena et al., 2015, Thompson and Travers, 2008)

Smyd5

SET and MYND domain containing, class 5

(FlyBase, 2017-, Jiang et al., 2017, Calpena et al., 2015, Schotta et al., 2004)

SmydA-1

SET and MYND domain containing, arthropod-specific, member 1

(Jiang et al., 2017, Calpena et al., 2015, Thompson and Travers, 2008)

SmydA-2

SET and MYND domain containing, arthropod-specific, member 2

(Jiang et al., 2017, Calpena et al., 2015, Thompson and Travers, 2008)

SmydA-3

SET and MYND domain containing, arthropod-specific, member 3

(Jiang et al., 2017, Calpena et al., 2015)

SmydA-4

SET and MYND domain containing, arthropod-specific, member 4

(Jiang et al., 2017, Calpena et al., 2015, Thompson and Travers, 2008)

SmydA-5

SET and MYND domain containing, arthropod-specific, member 5

(Jiang et al., 2017, Calpena et al., 2015, Thompson and Travers, 2008)

SmydA-6

SET and MYND domain containing, arthropod-specific, member 6

(Jiang et al., 2017, Calpena et al., 2015, Thompson and Travers, 2008, Schotta et al., 2004)

SmydA-7

SET and MYND domain containing, arthropod-specific, member 7

(Jiang et al., 2017, Calpena et al., 2015)

SmydA-8

SET and MYND domain containing, arthropod-specific, member 8

msta, EG:103B4.4

(Jiang et al., 2017, Calpena et al., 2015, Thompson and Travers, 2008, Schotta et al., 2004)

SmydA-9

SET and MYND domain containing, arthropod-specific, member 9

lincRNA.971

(Jiang et al., 2017, Calpena et al., 2015, Thompson and Travers, 2008, Schotta et al., 2004)

SET DOMAIN LYSINE METHYLTRANSFERASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

ash1

absent, small, or homeotic discs 1

ash-1, dash, absent, small or homeotic discs 1, ash

(Jiang et al., 2017, Dillon et al., 2005, Schotta et al., 2004)

CG4565

(Jiang et al., 2017, Schotta et al., 2004)

E(z)

Enhancer of zeste

EZ, pco, l(3)1902, Su(z)301, polycombeotic

(Jiang et al., 2017, Dillon et al., 2005, Schotta et al., 2004)

egg

eggless

dSETDB1, SetDB1, DmSetdb1, dEset

(Jiang et al., 2017, Mis et al., 2006, Schotta et al., 2004)

G9a

dG9a, EG:BACR37P7.2, EHMT

(Jiang et al., 2017, Mis et al., 2006, Schotta et al., 2004)

Hmt4-20

Histone methyltransferase 4-20

Suv4-20, Su(var)4-20, EG:115C2.10

(Jiang et al., 2017, Dillon et al., 2005, Schotta et al., 2004)

NSD

Nuclear receptor binding SET domain protein

Mes-4, dMes-4

(Jiang et al., 2017, Schotta et al., 2004)

Set1

SET domain containing 1

dSet1

(Jiang et al., 2017, Shilatifard, 2012, Mohan et al., 2011)

Set2

SET domain containing 2

dSet2, dHypb

(Jiang et al., 2017, Schotta et al., 2004)

Set8

SET domain containing 8

PR-Set7, l(3)neo41, Set7, dSet8

(Jiang et al., 2017, Dillon et al., 2005, Schotta et al., 2004)

Setd3

SET domain containing 3

(FlyBase, 2017-, Jiang et al., 2017, Schotta et al., 2004)

Su(var)3-9

Suppressor of variegation 3-9

SuVar3-9, Su-var(3)9, ptn, SUV39

(Jiang et al., 2017, Mis et al., 2006, Dillon et al., 2005, Schotta et al., 2004)

trr

trithorax-related

EG:63B12.3

(Jiang et al., 2017, Shilatifard, 2012, Mohan et al., 2011, Schotta et al., 2004)

trx

trithorax

l(3)j14A6, trxG, l(3)s5452, Trx-C, DMTRXIII

(Jiang et al., 2017, Shilatifard, 2012, Mohan et al., 2011, Dillon et al., 2005, Schotta et al., 2004)

TRNA METHYLTRANSFERASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Alkbh8

AlkBh8 tRNA methyltransferase

(FlyBase, 2017-)

CG1074

(FlyBase, 2017-)

CG4045

EG:22E5.4

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

fire dancer

(FlyBase, 2017-)

Mettl2

Methyltransferase like 2

metl

(FlyBase, 2017-)

Mt2

Methyltransferase 2

Dnmt2, dDnmt2, DNMT, DNA methyltransferase 2

(FlyBase, 2017-)

Nsun2

NOP2-Sun domain family, member 2

(FlyBase, 2017-)

Nsun6

NOP2/Sun RNA methyltransferase 6

(FlyBase, 2017-)

rswl

roswell

MRPP1

(FlyBase, 2017-)

Trm1

tRNA methyltransferase 1

(FlyBase, 2017-)

Trm7-32

tRNA methyltransferase 7-32

dTrm7_32

(FlyBase, 2017-)

Trm7-34

tRNA methyltransferase 7-34

dTrm7_34

(FlyBase, 2017-)

Trmt2a

tRNA methyltransferase 2a

(FlyBase, 2017-)

Trmt10A

tRNA methyltransferase 10A

(FlyBase, 2017-)

Trmt61

tRNA methyltransferase 61

(FlyBase, 2017-)

UNCLASSIFIED METHYLTRANSFERASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Bhmt

Betaine-homocysteine S-methyltransferase

(FlyBase, 2017-)

CG2906

(FlyBase, 2017-)

CG8067

(FlyBase, 2017-)

CG10621

selenocysteine methyltransferase

(FlyBase, 2017-)

CG11596

EG:39E1.1

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

Coenzyme Q3

(FlyBase, 2017-)

Coq5

Coenzyme Q5

(FlyBase, 2017-)

Gnmt

Glycine N-methyltransferase

(FlyBase, 2017-)

jhamt

juvenile hormone acid methyltransferase

BG:DS09218.5, DmJHAMT

(FlyBase, 2017-)

Thymidylate synthase

(FlyBase, 2017-)

UNCLASSIFIED PROTEIN-LYSINE N-METHYLTRANSFERASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG2614

38D.29

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

38C.42

(FlyBase, 2017-)

CG33230

(FlyBase, 2017-)

gpp

grappa

l(3)03342

(FlyBase, 2017-)

ham

hamlet

(FlyBase, 2017-)

Lpt

Lost PHDs of trr

cmi, cara mitad

(FlyBase, 2017-)

UNCLASSIFIED PROTEIN METHYLTRANSFERASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

agt

O-6-alkylguanine-DNA alkyltransferase

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

Diphthamide methyltransferase

l(3)L4910

(FlyBase, 2017-)

HemK1

HemK methyltransferase 1

(FlyBase, 2017-)

HemK2

HemK methyltransferase 2

(FlyBase, 2017-)

Ntmt

N-terminal methyltransferase

(FlyBase, 2017-)

UNCLASSIFIED RNA METHYLTRANSFERASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Amus

Another methylase of U6

(FlyBase, 2017-)

bin3

bicoid-interacting protein 3

(FlyBase, 2017-)

CG11342

(FlyBase, 2017-)

CG12128

(FlyBase, 2017-)

Hen1

Hen1 methyltransferase

Pimet, piRNA methyltransferase, DmHen1

(FlyBase, 2017-)

Mettl4

Methyltransferase like 4

ORF2

(FlyBase, 2017-)

Tgs1

Trimethylguanosine synthase 1

dtl, tat-like, l(3)S096713, Drosophila Tat-like, dTgs1

(FlyBase, 2017-)

External Data

Equivalent Group(s)

Human Methyltransferase families (HGNC)

Other resource(s)

Synonyms and Secondary IDs

Synonym(s)

METH

METHYLTRANSFERASES

Secondary FlyBase ID(s)

References (16)

Report Sections

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