FB2024_03 , released June 25, 2024
Gene Group - Macromolecular Complex: CSL-NOTCH-MASTERMIND TRANSCRIPTION FACTOR COMPLEX
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General Information
Name
CSL-NOTCH-MASTERMIND TRANSCRIPTION FACTOR COMPLEX
Species
D. melanogaster
Symbol
CNM
FlyBase ID
FBgg0001066
Date last reviewed
2023-08-08
Number of members
3
Description
Description
The CSL-Notch-Mastermind transcription factor complex consisting of the CSL protein, Su(H), and mastermind (mam) protein, in complex with Notch intracellular domain (generated by ligand-stimulated N-cleavage), up-regulates transcription of Notch-responsive genes. (Adapted from FBrf0232880).
Notes on Group

CSL is an acronym of CBF1/RBP-J, Su(H), Lag-1, the mammalian, fly, and worm orthologous proteins, respectively (FBrf0232880).

Source Material
The CSL-NOTCH-MASTERMIND TRANSCRIPTION FACTOR COMPLEX Gene Group has been compiled using the following publication(s): Yuan et al., 2016, Contreras et al., 2015, and Maier et al., 2011 .
Key Gene Ontology (GO) terms
Molecular Function
DNA-binding transcription factor activity, RNA polymerase II-specific
Biological Process
positive regulation of transcription by RNA polymerase II
Notch signaling pathway
Cellular Component
CSL-Notch-Mastermind transcription factor complex
Related Gene Groups
Other related group(s)
Notch Signaling Pathway Core Components
Members (3)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
mam
mastermind
N-2G
(Yuan et al., 2016, Contreras et al., 2015, Maier et al., 2011)
N
Notch
Ax, spl, fa, NICD, split
(Yuan et al., 2016, Contreras et al., 2015, Maier et al., 2011)
Su(H)
Suppressor of Hairless
l(2)br7, SuH, CSL, Supressor of Hairless, l(2)35Bh
(Yuan et al., 2016, Contreras et al., 2015, Maier et al., 2011)
External Data
Synonyms and Secondary IDs
Synonym(s)
CNM
CSL-NOTCH-MASTERMIND TRANSCRIPTION FACTOR COMPLEX
CSL-NICD-MAM ternary complex
CSL-NICD-MAM
Secondary FlyBase ID(s)
References (4)