FB2024_03 , released June 25, 2024
Gene Group - Macromolecular Complex: BETA CATENIN DESTRUCTION COMPLEX APC VARIANT
Open Close
General Information
Name
BETA CATENIN DESTRUCTION COMPLEX APC VARIANT
Species
D. melanogaster
Symbol
DES-C
FlyBase ID
FBgg0000896
Date last reviewed
2022-11-03
Number of members
4
Description
Description
The β-catenin destruction complex is a cytoplasmic protein complex that phosphorylates β-catenin, targeting it for ubiquitin-mediated proteolysis. In the absence of Wnt signaling, the β-catenin destruction complex constitutively suppresses the canonical Wnt signaling pathway by preventing the accumulation of cytoplasmic β-catenin (arm). (Adapted from FBrf0217546).
Notes on Group
Source Material
The BETA CATENIN DESTRUCTION COMPLEX APC VARIANT Gene Group has been compiled using the following publication(s): Yamulla et al., 2014 and Kunttas-Tatli et al., 2012 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
negative regulation of canonical Wnt signaling pathway
Cellular Component
beta-catenin destruction complex
Related Gene Groups
Parent group(s)
BETA CATENIN DESTRUCTION COMPLEXES
Members (4)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Apc
APC-like
APC1, D-APC, dAPC, adenomatous polyposis coli, dAPC1
(Kunttas-Tatli et al., 2012)
Axn
Axin
Daxin, d-axin, GSK3β, APC, l(3)S044230
(Yamulla et al., 2014)
CkIα
Casein kinase Iα
CK1, CK1α, CKI, CK I, Casein Kinase 1
(Yamulla et al., 2014)
sgg
shaggy
zw3, GSK3, GSK3β, GSK-3β, GSK-3
(Yamulla et al., 2014)
External Data
Synonyms and Secondary IDs
Synonym(s)
DES-C
Destruction complex; β-catenin destruction complex
BETA CATENIN DESTRUCTION COMPLEX APC VARIANT
BETA CATENIN DESTRUCTION COMPLEX
Secondary FlyBase ID(s)
References (3)