construct.
The expression of trxTRiP.cUa under the control of Scer\GAL44XHand induces some pre-adult lethality. Surviving adults show defects in heart morphology (i.e. lack heart tube and cardiac myofibrils, exhibit severely reduced collagen/Pericardin deposition and almost no cardioblast cells) and function (i.e. as shown by a significant decrease in brain staining after dye injection into the heart cavity), as compared to controls. Larvae also show significantly abnormal heart tube structure, with low cardiac myofibrillar density and significantly elevated collagen/Pericardin deposition.
Expression under the control of Scer\GAL4HCH.Hand does not induce significant lethality.