18kb genomic fragment containing the lncRNA:let7C locus; the mir-100, mir-let7 and mir-125 microRNAs have been deleted.
Adults transheterozygous for lncRNA:let7CKO2/Df(2L)let-7-CGKI and also bearing lncRNA:let7CΔmiRNAs and lncRNA:let7C3.3 are short lived, exhibit a progressive reduction in climbing ability and a progressive brain vacuolization.