FB2024_03 , released June 25, 2024
Allele: Dmel\Zasp52UAS.PR.GFP
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General Information
Symbol
Dmel\Zasp52UAS.PR.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0357207
Feature type
allele
Associated gene
Dmel\Zasp52
Associated Insertion(s)
Carried in Construct
M{UAS-GFP-Zasp52.PR}
Key Links
Transgenic product class
wild_type
(González-Morales et al., 2019)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(González-Morales et al., 2019)
Mutagen
in vitro construct
(González-Morales et al., 2019)
Progenitor genotype
Carried in construct
M{UAS-GFP-Zasp52.PR}
Cytology
Description

UAS regulatory sequences drive expression of the full-length Zasp52-PR isoform, tagged at the N-terminal end with GFP.

(González-Morales et al., 2019)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Zasp52
Tagged with
GFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  myofibrillar myopathy 4
      CEC
      (González-Morales et al., 2019)
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      FlyBase curator comment: "myofibrillar myopathy 4" is associated with mutations in the Zasp52 ortholog, human LDB3 (aka ZASP).

      (González-Morales et al., 2019)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing Zasp52UAS.PR.GFP under the control of Scer\GAL4Act88F.PB disrupts the sarcomere structure and leads to Z-disc aggregation in indirect flight muscles.

      (González-Morales et al., 2019)
      External Data
      Interactions
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Zasp52UAS.PR.GFP
      Name Synonyms
      Secondary FlyBase IDs
        References (1)