FB2024_03 , released June 25, 2024
Allele: Dmel\cryW420Y.UAS.EGFP
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General Information
Symbol
Dmel\cryW420Y.UAS.EGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0356462
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UAS regulatory sequences drive expression of full-length cry containing a point mutation (W420Y, with codon change of TGG to TAC), tagged with EGFP.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

When cry01 individuals are rescued by Scer\GAL4cry.PZ>cryW420Y.UAS.EGFP, I-LNv neurons show membrane potential depolarization to UV, blue and red light stimulation, but of much lower amplitude than controls; there is a much lower firing frequency after UV and blue light stimulation, dispute of a similar response duration, as compared to controls. These individuals predominantly arrhythmic under moderate-low constant light, as controls, but not under very low light.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescues
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
cryW420Y.UAS.EGFP
Name Synonyms
Secondary FlyBase IDs
    References (1)