FlyBase Allele Report: Hsap\MAP2K3[UAS.cSa]

General Information

Symbol

Hsap\MAP2K3^UAS.cSa

Species

H. sapiens

Name

UAS construct a of Sun

FlyBase ID

FBal0351735

Feature type

allele

Associated gene

Hsap\MAP2K3

Associated Insertion(s)

Carried in Construct

P{UAS-hMAP2K3.S}

Key Links

Transgenic product class

wild_type

(Sun et al., 2019)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Sun et al., 2019)

Mutagen

in vitro construct

(Sun et al., 2019)

Progenitor genotype

Carried in construct

P{UAS-hMAP2K3.S}

Cytology

Description

UAS regulates expression of the Hsap\MAP2K3 coding region.

(Sun et al., 2019)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\MAP2K3

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell migration | third instar larval stage, with Scer\GAL4^ptc.PU

(Sun et al., 2019)

Phenotype Manifest In

anterior-posterior compartment boundary of the wing disc | third instar larval stage, with Scer\GAL4^ptc.PU

(Sun et al., 2019)

Detailed Description

Statement

Reference

Expressing Hsap\MAP2K3^UAS.cSa under the control of Scer\GAL4^ptc.PU induces some cells at the wing disc A/P boundary to delaminate and migrate to the posterior compartment.

Expressing Hsap\MAP2K3^UAS.cSa under the control of Scer\GAL4^pnr.PU does not induce any obvious thorax defects.

(Sun et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Hsap\MAP2K3^UAS.cSa, Scer\GAL4^ptc.PU has abnormal cell migration | third instar larval stage phenotype, suppressible by puc^UAS.cUa, Scer\GAL4^ptc.PU

(Sun et al., 2019)

Hsap\MAP2K3^UAS.cSa, Scer\GAL4^ptc.PU has abnormal cell migration | third instar larval stage phenotype, suppressible by bsk^DN.UAS.cUa, Scer\GAL4^ptc.PU

(Sun et al., 2019)

NOT suppressed by

Statement

Reference

Hsap\MAP2K3^UAS.cSa, Scer\GAL4^ptc.PU has abnormal cell migration | third instar larval stage phenotype, non-suppressible by p38b^JF03341, Scer\GAL4^ptc.PU

(Sun et al., 2019)

Hsap\MAP2K3^UAS.cSa, Scer\GAL4^ptc.PU has abnormal cell migration | third instar larval stage phenotype, non-suppressible by p38b^DN.UAS, Scer\GAL4^ptc.PU

(Sun et al., 2019)

Enhancer of

Statement

Reference

Hsap\MAP2K3^UAS.cSa, Scer\GAL4^ptc.PU is an enhancer of abnormal cell migration | third instar larval stage phenotype of Scer\GAL4^ptc.PU, hep^UAS.cBa

(Sun et al., 2019)

Suppressor of

Statement

Reference

Hsap\MAP2K3^UAS.cSa, Scer\GAL4^pnr.PU is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^pnr.PU, lic^GD7546

(Sun et al., 2019)

Other

Statement

Reference

Hsap\MAP2K3^UAS.cSa, Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP has neoplasia | somatic clone | larval stage phenotype

(Sun et al., 2019)

Hsap\MAP2K3^UAS.cSa, Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP has abnormal cell migration | somatic clone | larval stage phenotype

(Sun et al., 2019)

Phenotype Manifest In

Suppressed by

Statement

Reference

Hsap\MAP2K3^UAS.cSa, Scer\GAL4^ptc.PU has anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype, suppressible by puc^UAS.cUa, Scer\GAL4^ptc.PU

(Sun et al., 2019)

Hsap\MAP2K3^UAS.cSa, Scer\GAL4^ptc.PU has anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype, suppressible by bsk^DN.UAS.cUa, Scer\GAL4^ptc.PU

(Sun et al., 2019)

NOT suppressed by

Statement

Reference

Hsap\MAP2K3^UAS.cSa, Scer\GAL4^ptc.PU has anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype, non-suppressible by p38b^JF03341, Scer\GAL4^ptc.PU

(Sun et al., 2019)

Hsap\MAP2K3^UAS.cSa, Scer\GAL4^ptc.PU has anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype, non-suppressible by p38b^DN.UAS, Scer\GAL4^ptc.PU

(Sun et al., 2019)

Enhancer of

Statement

Reference

Hsap\MAP2K3^UAS.cSa, Scer\GAL4^ptc.PU is an enhancer of anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype of Scer\GAL4^ptc.PU, hep^UAS.cBa

(Sun et al., 2019)

Suppressor of

Statement

Reference

Hsap\MAP2K3^UAS.cSa, Scer\GAL4^pnr.PU is a suppressor | partially of thoracic tergum phenotype of Scer\GAL4^pnr.PU, lic^GD7546

(Sun et al., 2019)

Other

Statement

Reference

Hsap\MAP2K3^UAS.cSa, Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP has eye disc | somatic clone phenotype

(Sun et al., 2019)

Hsap\MAP2K3^UAS.cSa, Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP has larval ventral nerve cord | somatic clone | larval stage phenotype

(Sun et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Whole-eye disc clones co-expressing Ras85D^V12.cUa.UAS and Hsap\MAP2K3^UAS.cSa under the control of Scer\GAL4^Act5C.PP frequently form tumors that invade into the VNC.

(Sun et al., 2019)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\MAP2K3^UAS.cSa

Name Synonyms

UAS construct a of Sun

Secondary FlyBase IDs

References (1)

Report Sections

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