FlyBase Allele Report: Dmel\lic[GD7546]

General Information

Symbol

Dmel\lic^GD7546

Species

D. melanogaster

Name

FlyBase ID

FBal0209927

Feature type

allele

Associated gene

Dmel\lic

Associated Insertion(s)

Carried in Construct

P{GD7546}

Also Known As

UAS-lic-IR

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD7546}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD7546

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates carcinoma

modeled by scrib^GD11666

(Sun et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal oxidative stress response, with Scer\GAL4^Ugt36A1.PK

(Lim et al., 2014)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible | adult stage, with Scer\GAL4^pnr.PU

(Sun et al., 2019)

Phenotype Manifest In

adult heart, with Scer\GAL4^Ugt36A1.PK

(Lim et al., 2014)

thoracic tergum, with Scer\GAL4^pnr.PU

(Sun et al., 2019)

Detailed Description

Statement

Reference

Expressing lic^GD7546 under the control of Scer\GAL4^pnr.PU induces a thorax cleft phenotype.

Expressing lic^GD7546 under the control of Scer\GAL4^GMR.PU produces no obvious eye phenotype.

(Sun et al., 2019)

Expression of lic^GD7546 under the control of Scer\GAL4^Dot.PK significantly increases the frequency of arrhythmias and causes age-dependent heart tube remodelling.

(Lim et al., 2014)

Adults expressing lic^GD7546 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

7546

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^pnr.PU, lic^GD7546 has visible | adult stage phenotype, enhanceable by bsk¹/bsk[+]

(Sun et al., 2019)

Suppressed by

Statement

Reference

Scer\GAL4^pnr.PU, lic^GD7546 has visible | adult stage phenotype, suppressible | partially by Hsap\MAP2K3^UAS.cSa, Scer\GAL4^pnr.PU

(Sun et al., 2019)

Scer\GAL4^pnr.PU, lic^GD7546 has visible | adult stage phenotype, suppressible by puc^E69/puc[+]

(Sun et al., 2019)

Suppressor of

Statement

Reference

lic^GD7546/Scer\GAL4^ptc.PU is a suppressor of abnormal cell migration | third instar larval stage phenotype of Scer\GAL4^ptc.PU, scrib^GD11666

(Sun et al., 2019)

lic^GD7546/Scer\GAL4^pnr-MD237 is a suppressor | partially of abnormal body color phenotype of Scer\GAL4^pnr-MD237, slim^GS10238

(Sekine et al., 2012)

lic^GD7546, Scer\GAL4^pnr-MD237 is a suppressor of abnormal body color phenotype of Ask1^{ΔN.UAS.Tag:FLAG}, Scer\GAL4^pnr-MD237

(Sekine et al., 2011)

NOT Suppressor of

Statement

Reference

lic^GD7546/Scer\GAL4^ptc.PU is a non-suppressor of abnormal cell migration | third instar larval stage phenotype of Scer\GAL4^ptc.PU, hep^UAS.cBa

(Sun et al., 2019)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^pnr.PU, lic^GD7546 has thoracic tergum phenotype, enhanceable by bsk¹/bsk[+]

(Sun et al., 2019)

Suppressed by

Statement

Reference

Scer\GAL4^pnr.PU, lic^GD7546 has thoracic tergum phenotype, suppressible by puc^E69/puc[+]

(Sun et al., 2019)

Scer\GAL4^pnr.PU, lic^GD7546 has thoracic tergum phenotype, suppressible | partially by Hsap\MAP2K3^UAS.cSa, Scer\GAL4^pnr.PU

(Sun et al., 2019)

Suppressor of

Statement

Reference

lic^GD7546/Scer\GAL4^ptc.PU is a suppressor of anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype of Scer\GAL4^ptc.PU, scrib^GD11666

(Sun et al., 2019)

lic^GD7546/Scer\GAL4^pnr-MD237 is a suppressor | partially of adult cuticle phenotype of Scer\GAL4^pnr-MD237, slim^GS10238

(Sekine et al., 2012)

lic^GD7546, Scer\GAL4^pnr-MD237 is a suppressor of adult thorax phenotype of Ask1^{ΔN.UAS.Tag:FLAG}, Scer\GAL4^pnr-MD237

(Sekine et al., 2011)

NOT Suppressor of

Statement

Reference

lic^GD7546/Scer\GAL4^ptc.PU is a non-suppressor of anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype of Scer\GAL4^ptc.PU, hep^UAS.cBa

(Sun et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of lic^GD7546 partially suppresses the melanisation of the adult thorax cuticle seen in flies expressing slim^GS10238 under the control of Scer\GAL4^pnr-MD237.

(Sekine et al., 2012)

Co-expression of lic^GD7546 abolishes the thorax pigmentation defects seen in Pk92B^{ΔN.Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^pnr-MD237 flies.

(Sekine et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v20166

w¹¹¹⁸; P{GD7546}v20166/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

7546

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

lic^GD7546

Name Synonyms

Secondary FlyBase IDs

References (15)

Report Sections

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