FB2024_03 , released June 25, 2024
Allele: Dmel\MCUUAS.cTa
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General Information
Symbol
Dmel\MCUUAS.cTa
Species
D. melanogaster
Name
UAS construct a of Tufi
FlyBase ID
FBal0351718
Feature type
allele
Associated gene
Dmel\MCU
Associated Insertion(s)
Carried in Construct
P{UAS-MCU.T}
Key Links
Transgenic product class
cDNA
(Tufi et al., 2019)
wild_type
(Tufi et al., 2019)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Tufi et al., 2019)
wild_type
(Tufi et al., 2019)
Mutagen
in vitro construct
(Tufi et al., 2019)
Progenitor genotype
Carried in construct
P{UAS-MCU.T}
Cytology
Description

UASt regulates expression of MCU (cDNA clone LD26402, equivalent to isoforms A, B, C and D).

(Tufi et al., 2019)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
MCU
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Friedreich ataxia 1
      modeled by fhRNAi.UAS.cAa
      (Rodríguez et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of MCUUAS.cTa under the control of Scer\GAL4GMR.PF does not affect eye or ommatidial morphology, compared to controls.

      (Tufi et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      NOT suppressed by
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of MCUUAS.cTa and EMREUAS.Tag:MYC under the control of Scer\GAL4GMR.PF results in dramatic eye morphology defects, compared to controls, including loss of retinal pigment and ommatidia, with occasional black, necrotic patches; these effects are not seen with expression of either transgene alone.

      Expression of MCUUAS.cTa and any one of MICU1UAS.ORF.Tag:HA, MICU1B.UAS.Tag:HA, MICU3A.UAS.Tag:V5 or MICU3C.UAS.Tag:V5, under the control of Scer\GAL4GMR.PF results in mild disruption of ommatidial arrangement, compared to controls; this is not seen with expression of any of these transgenes alone.

      (Tufi et al., 2019)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      MCUUAS.cTa
      Name Synonyms
      UAS construct a of Tufi
      Secondary FlyBase IDs
        References (2)