FB2024_03 , released June 25, 2024
Allele: Dmel\kmr1
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General Information
Symbol
Dmel\kmr1
Species
D. melanogaster
Name
FlyBase ID
FBal0350248
Feature type
allele
Associated gene
Dmel\kmr
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Shami Shah et al., 2019)
Mutagen
CRISPR/Cas9
(Shami Shah et al., 2019)
Progenitor genotype
Cytology
Description

A 1 bp deletion creating a frameshift mutation starting at the 89th codon.

(Shami Shah et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:13,745,762..13,745,762 [+]
Comment:

A 1bp deletion early in the kmr coding region causes a frameshift.

(Shami Shah et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      kmr1/kmr1 flies display misoriented hair patterns on the wing, thorax and eyes, while heterozygotes exhibit phenotypes similar to wild-type controls. A misoriented wing hair pattern can also be observed in kmr1/Df(3R)Exel6170 flies, but not in +/Df(3R)Exel6170 heterozygotes.

      kmr1/kmr1 pupae lose the asymmetric distribution of planar cell polarity proteins in the wing disc epithelium characteristic of controls.

      (Shami Shah et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Double-heterozygous flies of the genotype kmr1/+ together with dsh[1]/+, dsh[3]/+ or dsh[75]/+ display misoriented hair patterns on the wing, thorax and eyes, while single heterozygotes exhibit phenotypes similar to wild-type controls.

      (Shami Shah et al., 2019)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      kmr1
      (Shami Shah et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)