FlyBase Allele Report: Dmel\Dscam2[10B]

General Information

Symbol

Dmel\Dscam2^10B

Species

D. melanogaster

Name

FlyBase ID

FBal0346126

Feature type

allele

Associated gene

Dmel\Dscam2

Associated Insertion(s)

TI{TI}Dscam2^10B

Carried in Construct

Key Links

Allele class

Mutagen

phiC31 integrase

Nature of the Allele

Allele class

Mutagen

phiC31 integrase

(Lah et al., 2014)

Progenitor genotype

TI{TI}Dscam2^founder

(Lah et al., 2014)

Associated Insertion(s)

TI{TI}Dscam2^10B

Cytology

Description

Insertion of cDNA containing exon 10B into the attP site within the TI{TI}Dscam2^founder line, resulting in a single Dscam2 isoform being expressed from the endogenous locus.

(Lah et al., 2014)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage (with Dscam2^10A)

(Lah et al., 2014)

abnormal neuroanatomy | adult stage | recessive

(Lah et al., 2014)

abnormal neuroanatomy | adult stage | recessive | somatic clone

(Lah et al., 2014)

abnormal size | adult stage (with Dscam2^10A)

(Lah et al., 2014)

abnormal size | adult stage | recessive

(Lah et al., 2014)

abnormal size | adult stage | recessive | somatic clone

(Lah et al., 2014)

partially lethal - majority die (with Dscam2^10A)

(Lah et al., 2014)

partially lethal - majority die | recessive

(Lah et al., 2014)

Phenotype Manifest In

lamina monopolar neuron L1

(Lah et al., 2014)

lamina monopolar neuron L1 (with Dscam2^10A)

(Lah et al., 2014)

lamina monopolar neuron L1 | somatic clone

(Lah et al., 2014)

lamina monopolar neuron L2

(Lah et al., 2014)

lamina monopolar neuron L2 (with Dscam2^10A)

(Lah et al., 2014)

lamina monopolar neuron L2 | somatic clone

(Lah et al., 2014)

Detailed Description

Statement

Reference

In Dscam2^10B/Dscam2^10B and Dscam2^10A/Dscam2^10B flies lamina monopolar neurons L1 and L2 have significantly reduced axonal arbors in their respective correctly targeted medulla layers. Axonal tiling within medulla columns is maintained and the gross morphology of the optic lobe is indistinguishable from wild-type controls.

Dscam2^10B/Dscam2^10B somatic clones of lamina monopolar neurons L1 in a Dscam2^10B/+ background have slightly (but significantly) constricted axonal arbors in medulla layers M1 and M5 and no defects in tiling within medulla columns. Somatic clones of lamina monopolar neurons L2 have a severe arbor constriction phenotype in medulla layer M2.

(Lah et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Dscam2^10B

(Kerwin et al., 2018, Lah et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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