FB2024_03 , released June 25, 2024
Allele: Dmel\Dscam210A
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General Information
Symbol
Dmel\Dscam210A
Species
D. melanogaster
Name
FlyBase ID
FBal0346124
Feature type
allele
Associated gene
Dmel\Dscam2
Associated Insertion(s)
TI{TI}Dscam210A
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
phiC31 integrase
(Lah et al., 2014)
Progenitor genotype
TI{TI}Dscam2founder
(Lah et al., 2014)
Associated Insertion(s)
TI{TI}Dscam210A
Cytology
Description

Insertion of cDNA containing exon 10A into the attP site within the TI{TI}Dscam2founder line, resulting in a single Dscam2 isoform being expressed from the endogenous locus.

(Lah et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In Dscam210A/Dscam210A and Dscam210A/Dscam210B flies lamina monopolar neurons L1 and L2 have significantly reduced axonal arbors in their respective correctly targeted medulla layers. Axonal tiling within medulla columns is maintained and the gross morphology of the optic lobe is indistinguishable from wild-type controls.

      Dscam210A/Dscam210A somatic clones of lamina monopolar neurons L1 in a Dscam210A/+ background have severely constricted axonal arbors in medulla layer M1 (nut not M5) and some display a tiling defect: axonal arbors extend laterally into neighbouring columns in medulla layers M1 and/or M5. Somatic clones of lamina monopolar neurons L2 display a similar arbor morphology to wild-type controls.

      (Lah et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Dscam210A
      (Kerwin et al., 2018, Lah et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)