FlyBase Allele Report: Hsap\MAPT[UAS.cUa]

General Information

Symbol

Hsap\MAPT^UAS.cUa

Species

H. sapiens

Name

UAS construct a of Unknown

FlyBase ID

FBal0343939

Feature type

allele

Associated gene

Hsap\MAPT

Associated Insertion(s)

Carried in Construct

P{UAS-hMAPT.U}

Also Known As

UAS-Tau, UAS-Tau^WT

Key Links

Transgenic product class

wild_type

(Lasagna-Reeves et al., 2016)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Lasagna-Reeves et al., 2016)

Mutagen

in vitro construct

(Lasagna-Reeves et al., 2016)

Progenitor genotype

Carried in construct

P{UAS-hMAPT.U}

Cytology

Description

UAS regulatory sequences drive expression of Hsap\MAPT.

(Lasagna-Reeves et al., 2016)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\MAPT

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of tauopathy

CEA

(Kim et al., 2021, Lasagna-Reeves et al., 2016)

CEA with Hsap\RAPGEF3^{Epac1-camps.UAS}

(Dissel et al., 2017)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of tauopathy

is ameliorated by CG5567^GD11694

(Kim et al., 2021)

is ameliorated by CG8888^EY12413

(Kim et al., 2021)

is ameliorated by CG6154^MI08916

(Kim et al., 2021)

is ameliorated by Cont^GD12610

(Kim et al., 2021)

is ameliorated by CG7137^GD12147

(Kim et al., 2021)

is exacerbated by CG7896^KK105990

(Kim et al., 2021)

is exacerbated by Cox11^KK100158

(Kim et al., 2021)

is ameliorated by sro^GD7469

(Kim et al., 2021)

is ameliorated by Dgkε^ox-1

(Kim et al., 2021)

is exacerbated by E2f1^KK100304

(Kim et al., 2021)

is ameliorated by Hydr2^MI08405

(Kim et al., 2021)

is ameliorated by Thg^GD11217

(Kim et al., 2021)

is exacerbated by VhaM9.7-a^KK107389

(Kim et al., 2021)

is ameliorated by kek3^GD1733

(Kim et al., 2021)

is ameliorated by kek5^MI01444

(Kim et al., 2021)

is exacerbated by plx^KK100306

(Kim et al., 2021)

is exacerbated by Nuak^EY22355

(Lasagna-Reeves et al., 2016)

is ameliorated by Nuak^GD7410

(Lasagna-Reeves et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology | adult stage, with Scer\GAL4^ninaE.PU

(Hsieh et al., 2019)

abnormal wound healing | RU486 conditional, with Scer\GAL4^{repo.Switch.2301}

(Byrns et al., 2021)

increased mortality | RU486 conditional, with Scer\GAL4^{repo.Switch.2301}

(Byrns et al., 2021)

Phenotype Manifest In

adult brain | conditional, with Scer\GAL4^{repo.Switch.2301}

(Byrns et al., 2021)

retina, with Scer\GAL4^ninaE.PU

(Hsieh et al., 2019)

Detailed Description

Statement

Reference

Expression of Hsap\MAPT^UAS.cUa under the control of Scer\GAL4^ninaE.PU reduces electroretinogram amplitude in 5 day old adults, compared to controls.

(Hsieh et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\MAPT^UAS.cUa, Scer\GAL4^ninaE.PU has abnormal neurophysiology | adult stage phenotype, enhanceable by snRNP-U1-70K^HMS00274, Scer\GAL4^ninaE.PU

(Hsieh et al., 2019)

Hsap\MAPT^UAS.cUa, Scer\GAL4^ninaE.PU has abnormal neurophysiology | adult stage phenotype, enhanceable by snf[+]/snf^J210

(Hsieh et al., 2019)

Hsap\MAPT^UAS.cUa, Scer\GAL4^ninaE.PU has abnormal neurophysiology | adult stage phenotype, enhanceable by SmE^HMS00074, Scer\GAL4^ninaE.PU

(Hsieh et al., 2019)

Hsap\MAPT^UAS.cUa, Scer\GAL4^ninaE.PU has abnormal neurophysiology | adult stage phenotype, enhanceable by SmD2^HMC03839, Scer\GAL4^ninaE.PU

(Hsieh et al., 2019)

Hsap\MAPT^UAS.cUa, Scer\GAL4^ninaE.PU has abnormal neurophysiology | adult stage phenotype, enhanceable by snRNP-U1-C^GD11660, Scer\GAL4^ninaE.PU

(Hsieh et al., 2019)

Hsap\MAPT^UAS.cUa, Scer\GAL4^ninaE.PU has abnormal neurophysiology | adult stage phenotype, enhanceable by SmB^{MI07584-GFSTF.0}/SmB[+]

(Hsieh et al., 2019)

NOT Enhanced by

Statement

Reference

Hsap\MAPT^UAS.cUa, Scer\GAL4^ninaE.PU has abnormal neurophysiology | adult stage phenotype, non-enhanceable by snRNP-U1-70K[+]/snRNP-U1-70K²

(Hsieh et al., 2019)

Suppressed by

Statement

Reference

Hsap\MAPT^UAS.cUa, Scer\GAL4^{repo.Switch.2301} has increased mortality phenotype, suppressible | partially by kay^DN.UAS, Scer\GAL4^{repo.Switch.2301}

(Byrns et al., 2021)

Hsap\MAPT^UAS.cUa, Scer\GAL4^{repo.Switch.2301} has abnormal wound healing phenotype, suppressible | partially by kay^DN.UAS, Scer\GAL4^{repo.Switch.2301}

(Byrns et al., 2021)

Hsap\MAPT^UAS.cUa, Scer\GAL4^{repo.Switch.2301} has increased mortality phenotype, suppressible | partially by puc^UAS.cUa, Scer\GAL4^{repo.Switch.2301}

(Byrns et al., 2021)

Hsap\MAPT^UAS.cUa, Scer\GAL4^{repo.Switch.2301} has abnormal wound healing phenotype, suppressible | partially by puc^UAS.cUa, Scer\GAL4^{repo.Switch.2301}

(Byrns et al., 2021)

NOT suppressed by

Statement

Reference

Hsap\MAPT^UAS.cUa, Scer\GAL4^ninaE.PU has abnormal neurophysiology | adult stage phenotype, non-suppressible by snRNP-U1-70K[+]/snRNP-U1-70K²

(Hsieh et al., 2019)

Suppressor of

Statement

Reference

Hsap\MAPT^UAS.cUa, Scer\GAL4^ninaE.PU is a suppressor of abnormal neurophysiology | adult stage phenotype of Scer\GAL4^ninaE.PU, snRNP-U1-C^GD11660

(Hsieh et al., 2019)

Scer\GAL4^ninaE.PU/Hsap\MAPT^UAS.cUa is a suppressor of abnormal neurophysiology | dominant | adult stage phenotype of snRNP-U1-70K²

(Hsieh et al., 2019)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\MAPT^UAS.cUa, Scer\GAL4^ninaE.PU has retina phenotype, enhanceable by snRNP-U1-70K^HMS00274, Scer\GAL4^ninaE.PU

(Hsieh et al., 2019)

Hsap\MAPT^UAS.cUa, Scer\GAL4^ninaE.PU has retina phenotype, enhanceable by snf[+]/snf^J210

(Hsieh et al., 2019)

Hsap\MAPT^UAS.cUa, Scer\GAL4^ninaE.PU has retina phenotype, enhanceable by SmE^HMS00074, Scer\GAL4^ninaE.PU

(Hsieh et al., 2019)

Hsap\MAPT^UAS.cUa, Scer\GAL4^ninaE.PU has retina phenotype, enhanceable by SmD2^HMC03839, Scer\GAL4^ninaE.PU

(Hsieh et al., 2019)

Hsap\MAPT^UAS.cUa, Scer\GAL4^ninaE.PU has retina phenotype, enhanceable by snRNP-U1-C^GD11660, Scer\GAL4^ninaE.PU

(Hsieh et al., 2019)

Hsap\MAPT^UAS.cUa, Scer\GAL4^ninaE.PU has retina phenotype, enhanceable by SmB^{MI07584-GFSTF.0}/SmB[+]

(Hsieh et al., 2019)

NOT Enhanced by

Statement

Reference

Hsap\MAPT^UAS.cUa, Scer\GAL4^ninaE.PU has retina phenotype, non-enhanceable by snRNP-U1-70K[+]/snRNP-U1-70K²

(Hsieh et al., 2019)

Suppressed by

Statement

Reference

Hsap\MAPT^UAS.cUa, Scer\GAL4^{repo.Switch.2301} has adult brain | conditional phenotype, suppressible by puc^UAS.cUa, Scer\GAL4^{repo.Switch.2301}

(Byrns et al., 2021)

NOT suppressed by

Statement

Reference

Hsap\MAPT^UAS.cUa, Scer\GAL4^ninaE.PU has retina phenotype, non-suppressible by snRNP-U1-70K[+]/snRNP-U1-70K²

(Hsieh et al., 2019)

Suppressor of

Statement

Reference

Hsap\MAPT^UAS.cUa, Scer\GAL4^ninaE.PU is a suppressor of retina phenotype of Scer\GAL4^ninaE.PU, snRNP-U1-C^GD11660

(Hsieh et al., 2019)

Scer\GAL4^ninaE.PU/Hsap\MAPT^UAS.cUa is a suppressor of retina phenotype of snRNP-U1-70K²

(Hsieh et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\MAPT^UAS.cUa

Name Synonyms

UAS construct a of Unknown

Secondary FlyBase IDs

References (12)

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