FB2024_03 , released June 25, 2024
Allele: Dmel\ash1R1464A
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General Information
Symbol
Dmel\ash1R1464A
Species
D. melanogaster
Name
FlyBase ID
FBal0343528
Feature type
allele
Associated gene
Dmel\ash1
Associated Insertion(s)
Carried in Construct
PBac{ash1.R1464A}
Key Links
Transgenic product class
missense_variant
(Schmähling et al., 2018)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Schmähling et al., 2018)
Mutagen
in vitro construct
(Schmähling et al., 2018)
Progenitor genotype
Carried in construct
PBac{ash1.R1464A}
Cytology
Description

Genomic fragment ( 3L:19600040..19590604 , release 6 coordinates) that encompasses ash1 (sequence is derived from BAC clone CH322-147P9). The ash1 coding sequence has been mutated to carry the R1464A amino acid replacement. Coding sequence from the Taf6 gene is also present in this fragment; multiple ATG initiation codons in this CDS have been converted into stop codons.

(Schmähling et al., 2018)
Allele components
Component
Use(s)
Regulatory region(s)
ash1
Encoded product / tool
ash1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      ash1R1464A partially rescues ash122

      (Schmähling et al., 2018)
      Comments

      ash1R1464A expressing ash122/ash122 animals that contain maternally deposited wild-type Ash1 protein and zygotically expressed Ash1 protein with the R1464A point mutation are fertile.

      ash1R1464A/+ expressing ash122/ash122 animals that contain maternally deposited and zygotically expressed Ash1 protein with the R1464A point mutation exhibit similar homeotic transformations as ash122/ash122 pharate adults. A substantial fraction of them eclose from the pupal case but die in 1-2 days.

      (Schmähling et al., 2018)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ash1R1464A
      (Schmähling et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)