FB2024_03 , released June 25, 2024
Allele: Dmel\Sema1aΔ5.UAS
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General Information
Symbol
Dmel\Sema1aΔ5.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0335706
Feature type
allele
Associated gene
Dmel\Sema1a
Associated Insertion(s)
Carried in Construct
PBac{UAS-Sema1a.Δ5}
Key Links
Transgenic product class
inframe_deletion
(Jeong et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Jeong et al., 2017)
Mutagen
in vitro construct
(Jeong et al., 2017)
Progenitor genotype
Carried in construct
PBac{UAS-Sema1a.Δ5}
Cytology
Description

UASt regulatory sequences drive expression of an internally deleted form of Sema1a.

(Jeong et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Sema1a
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Sema1aΔ5.Scer\UAS under the control of Scer\GAL4elav.PLu in embryos does not induce significant increase in axon pathfinding defects relative to controls.

      (Jeong et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The moderate axon pathfinding defects (defasciculation defects in intersegmental nerve b, ISNb, motor axons very infrequent lateral axon tract disruptions in the central nervous system) characteristic for embryos expressing pblScer\UAS.N.T:Ivir\HA1 under the control of Scer\GAL4elav.PLu are partially exacerbated by co-expression of Sema1aΔ5.Scer\UAS (it increases the frequency of defects in the central nervous system but not in the ISNb) and in addition, the embryos also display midline crossing defects.

      (Jeong et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Sema1aΔ5.UAS/Scer\GAL4sca-537.4 partially rescues Sema1ak13702

      (Jeong et al., 2017)
      Comments

      Expression of Sema1aΔ5.Scer\UAS under the control of Scer\GAL4sca-537.4 strongly rescues the axon guidance defects characteristic for Sema1ak13702 homozygous embryos - the defects in the central nervous system are almost completely suppressed but the frequency of defasciculation irregularities in the intersegmental nerve b is only partially decreased and remains elevated compared to wild-type controls.

      (Jeong et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Sema1aΔ5.Scer\UAS
      Sema1aΔ5.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)