FB2024_03 , released June 25, 2024
Allele: Dmel\TmhsP1
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General Information
Symbol
Dmel\TmhsP1
Species
D. melanogaster
Name
FlyBase ID
FBal0325541
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
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    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
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    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Heterozygotes do not exhibit any gross defects in external bristle morphology.

    Compared to controls, heterozygous mutants show a reduced response to an auditory stimulus mimicking flies' courtship song.

    External Data
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    Xenogenetic Interactions
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    Complementation and Rescue Data
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    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer

    FlyBase curator comment: The flanking sequence of the P{hsneo}CG2021neo7 insertion in the 'l(3)neo7' line maps within the CG2021 gene (see FBrf0230166). The cytological location of the insertion inferred from the flanking sequence location is 62B4 (FBrf0230166), which is consistent with the cytological location of 62B determined for the insertion by in situ hybridisation (FBrf0049003) and with the complementation data for the lethality of the line (FBrf0049893, FBrf0111489). However, FBrf0206525 states that the 'l(3)neo7' line affects CG12026 (the annotation corresponding to Tmhs), which is located over 100kB from the site of the P{hsneo}CG2021neo7 insertion. Tmhs is an ortholog of the human LHFPL5 (or 'TMHS') gene, mutations of which are associated with deafness, and FBrf0206525 shows that heterozygotes of the 'l(3)neo7' line have a defect in the sound-evoked potential in response to an acoustic stimulus. There is no information in FBrf0206525 to help determine whether there is a second insertion, in CG12026, in the 'l(3)neo7' line. For now, this discrepancy is represented in FlyBase by assuming that there are two separable lesions in the 'l(3)neo7' line: 1. the P{hsneo}CG2021neo7 insertion in the CG2021 gene, to which the lethality of the line (represented by the CG2021neo7 allele) is assumed to map (as the complementation data is consistent with this interpretation) and 2. a lesion that affects Tmhs and which results in an auditory defect (represented by the TmhsP1 allele). ( date:20170227 ).

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
    Reported As
    Symbol Synonym
    Tmhs1
    TmhsP1
    Name Synonyms
    Secondary FlyBase IDs
    • FBal0009644
    • FBal0011031
    References (2)