FB2024_03 , released June 25, 2024
Allele: Dmel\Pak6-2
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General Information
Symbol
Dmel\Pak6-2
Species
D. melanogaster
Name
FlyBase ID
FBal0324747
Feature type
allele
Associated gene
Dmel\Pak
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - molecular evidence

    (Kamiyama et al., 2015)
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Pak6-2 homozygous and Pak6-2/Pak4 transheterozygous embryos show defects in dendritogenesis in the embryonic aCC motoneurons (decreased number of dendritic tips, misplacement of primary branches) compared to controls.

        (Kamiyama et al., 2015)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Other
        Statement
        Reference

        Dscam121/Dscam1[+], Pak6-2 has abnormal neuroanatomy | embryonic stage phenotype

        (Kamiyama et al., 2015)
        Phenotype Manifest In
        Other
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Pak6-2;Dscam121 double heterozygous mutants display defects in dendritogenesis in the embryonic aCC motoneurons (decreased number of dendritic tips), which are not seen in either of the single heterozygotes.

        (Kamiyama et al., 2015)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Pak6-2 is rescued by Scer\GAL4eve.RN2/PakUAS.mEos2

        (Kamiyama et al., 2015)
        Comments

        The dendritogenesis defects (reduced number of dendritic tips) in the embryonic aCC motoneurons characteristic for Pak6-2 homozygotes are rescued by expression of PakScer\UAS.T:Lhem\EosFP-m2 under the control of Scer\GAL4eve.RN2 in the mutant background.

        (Kamiyama et al., 2015)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Pak6-2
        pak16-2
        (Kamiyama et al., 2015)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)