FlyBase Allele Report: Dmel\HERC2[G17171]

General Information

Symbol

Dmel\HERC2^G17171

Species

D. melanogaster

Name

FlyBase ID

FBal0323552

Feature type

allele

Associated gene

Dmel\HERC2

Associated Insertion(s)

P{EP}HERC2^G17171

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{EP}HERC2^G17171

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:20,394,400..20,394,400 [+]

(Imai et al., 2015)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage, with Scer\GAL4^ple.PU

(Imai et al., 2015)

decreased cell number | adult stage, with Scer\GAL4^ple.PU

(Imai et al., 2015)

Phenotype Manifest In

dopaminergic PPM1 neuron | adult stage, with Scer\GAL4^ple.PU

(Imai et al., 2015)

dopaminergic PPM2 neuron | adult stage, with Scer\GAL4^ple.PU

(Imai et al., 2015)

Detailed Description

Statement

Reference

Expression of HERC2^G17171 under the control of Scer\GAL4^ple.PU (together with tub-Gal80[ts] to limit the time of expression to adulthood) results in a loss of dopaminergic neurons from the PPM1/2 cluster in the adult brain.

(Imai et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Scer\GAL4^dpp.PU/HERC2^G17171 is an enhancer of visible | adult stage phenotype of neur^{ΔRING.UAS.EGFP}

(Imai et al., 2015)

NOT Enhancer of

Statement

Reference

HERC2^G17171, Scer\GAL4^dpp.PU is a non-enhancer of visible | adult stage phenotype of Scer\GAL4^dpp.PU, Ser^UAS.cUa

(Imai et al., 2015)

Scer\GAL4^dpp.PU/HERC2^G17171 is a non-enhancer of visible | adult stage phenotype of N^55e11

(Imai et al., 2015)

Other

Statement

Reference

Delta^UAS.cUa, HERC2^G17171, Scer\GAL4^dpp.PU has visible | adult stage phenotype

(Imai et al., 2015)

HERC2^G17171, Scer\GAL4^dpp.PU, neur^UAS.cUa has visible | adult stage phenotype

(Imai et al., 2015)

HERC2^G17171, Scer\GAL4^dpp.PU, neur^UAS.cUa has abnormal size | adult stage phenotype

(Imai et al., 2015)

Phenotype Manifest In

Enhancer of

Statement

Reference

Scer\GAL4^dpp.PU/HERC2^G17171 is an enhancer of wing margin phenotype of neur^{ΔRING.UAS.EGFP}

(Imai et al., 2015)

NOT Enhancer of

Statement

Reference

HERC2^G17171, Scer\GAL4^dpp.PU is a non-enhancer of wing margin bristle | increased number phenotype of Scer\GAL4^dpp.PU, Ser^UAS.cUa

(Imai et al., 2015)

Scer\GAL4^dpp.PU/HERC2^G17171 is a non-enhancer of wing vein | adult stage phenotype of N^55e11

(Imai et al., 2015)

Other

Statement

Reference

Delta^UAS.cUa, HERC2^G17171, Scer\GAL4^dpp.PU has wing margin phenotype

(Imai et al., 2015)

HERC2^G17171, Scer\GAL4^dpp.PU, neur^UAS.cUa has wing | adult stage phenotype

(Imai et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Flies expressing Dl^Scer\UAS.cUa under the control of Scer\GAL4^dpp.PU and kept at 18[o]C do not display any overt wing phenotype but show notching of the wing margin upon co-expression of HERC2^G17171.

The ectopic wing margin bristle phenotype characteristic for adult flies expressing Ser^Scer\UAS.cUa under the control of Scer\GAL4^dpp.PU is not significantly modified by co-expression of HERC2^G17171.

The vein thickening and ectopic veins phenotype characteristic for N^55e11 mutant adults is not modified by expression of HERC2^G17171 under the control of Scer\GAL4^dpp.PU in the mutant background.

The wing notching phenotype characteristic for adults expressing neur^{ΔRING.Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^dpp.PU is exacerbated by co-expression of HERC2^G17171.

The total area of adult wings in flies co-expressing neur^Scer\UAS.cUa and HERC2^G17171 under the control Scer\GAL4^dpp.PU is significantly reduced compared to controls (as is the area where the Scer\GAL4^dpp.PU driver is expressed). No such size decrease is apparent when neur^Scer\UAS.cUa is expressed alone.

(Imai et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

33296

w^* P{EP}HERC2^G17171

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

HERC2^G17171

dHERC2^EP

(Imai et al., 2015)

dHERC2^p[45]G17171

(Imai et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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