Mutation affecting the pnt-P1 isoform. Indel in the P1-specific exon 1, resulting in a frameshift and premature stop codon that deletes the 535 C-terminal amino acids (including the Ets DNA-binding domain).
4 bp deletion causes a frameshift after amino acid 88 and early translation termination.
pntP1-82/pntP1-82 mutants are late third instar lethal.
pntP1-82/pntP1-82 mutant larval brains exhibit a significant decrease in both the number of Asense-negative type II neuroblasts and the number of intermediate neural progenitors.
pntP1-82/pntΔ88 mutant larval brains have a significant increase in the number of Asense-negative type II neuroblasts, but a significant decrease in the number of intermediate neural progenitors.
