FB2024_03 , released June 25, 2024
Allele: Dmel\CCHa2CR-1
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General Information
Symbol
Dmel\CCHa2CR-1
Species
D. melanogaster
Name
FlyBase ID
FBal0320379
Feature type
allele
Associated gene
Dmel\CCHa2
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Sano et al., 2015)
Progenitor genotype
Cytology
Description

8bp deletion within the coding region of the mature CCHa2 peptide, resulting in a frameshift. The mature peptide produced is predicted to be GCQAYGHVWSWQA instead of the wild-type GCQAYGHVCYGGH sequence.

(Sano et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      CCHa2CR-1 mutants show a delay in pupation in a high sugar diet.

      (Havula et al., 2022)

      CCHa2CR-1/Df(3R)Exel7320 mid-third instar larvae have significantly reduced body weight compared to controls, the effect is seen in both sexes.

      (Sano et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      CCHa2CR-1 is partially rescued by CCHa2UAS.cSa

      (Sano et al., 2015)
      Comments

      Expression of CCHa2Scer\UAS.cSa under the control of Scer\GAL4Cg.PA strongly rescues the reduced body weight characteristic for CCHa2CR-1/Df(3R)Exel7320 mid-third instar larvae. Significant rescue is observed in both sexes.

      (Sano et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CCHa2 CR1
      (Yamagata et al., 2022)
      CCHa2CR-1
      (Yamagata et al., 2022, Sano et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)