FlyBase Allele Report: Dmel\Drp1[UAS.cUa]

General Information

Symbol

Dmel\Drp1^UAS.cUa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Unknown

FlyBase ID

FBal0320374

Feature type

allele

Associated gene

Dmel\Drp1

Associated Insertion(s)

Carried in Construct

P{UAS-Drp1.U}

Also Known As

UAS-Drp1

Key Links

Transgenic product class

wild_type

(Chao et al., 2016)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Chao et al., 2016)

Mutagen

in vitro construct

(Chao et al., 2016)

Progenitor genotype

Carried in construct

P{UAS-Drp1.U}

Cytology

Description

UAS regulatory sequences drive expression of Drp1.

(Chao et al., 2016)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Drp1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

flight muscle cell | adult stage, with Scer\GAL4^Mef2.247

(Chen et al., 2020)

mitochondrion | adult stage, with Scer\GAL4^Mef2.247

(Chen et al., 2020)

Detailed Description

Statement

Reference

Expressing Drp1^UAS.cUa under the control of Scer\GAL4^Mef2.247 leads to smaller and rounder mitochondria in adult flight muscles.

(Chen et al., 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Drp1^UAS.cUa, Scer\GAL4^GMR.PU is a non-enhancer of visible | adult stage phenotype of Hsap\FUS^{WT.UAS.RFP(Unk),Tag:HA}, Scer\GAL4^GMR.PU

(Deng et al., 2015)

Drp1^UAS.cUa, Scer\GAL4^GMR.PU is a non-enhancer of abnormal eye color | adult stage phenotype of Hsap\FUS^{WT.UAS.RFP(Unk),Tag:HA}, Scer\GAL4^GMR.PU

(Deng et al., 2015)

Drp1^UAS.cUa, Scer\GAL4^GMR.PU is a non-enhancer of visible | adult stage phenotype of Hsap\FUS^{P525L.UAS.RFP(Unk),Tag:HA}, Scer\GAL4^GMR.PU

(Deng et al., 2015)

Drp1^UAS.cUa, Scer\GAL4^GMR.PU is a non-enhancer of abnormal eye color | adult stage phenotype of Hsap\FUS^{P525L.UAS.RFP(Unk),Tag:HA}, Scer\GAL4^GMR.PU

(Deng et al., 2015)

Suppressor of

Statement

Reference

Scer\GAL4^Mef2.PU/Drp1^UAS.cUa is a suppressor | partially of increased mortality during development phenotype of clu^f04554

(Yang et al., 2022)

Scer\GAL4^Mef2.PU/Drp1^UAS.cUa is a suppressor of increased cell death | adult stage phenotype of clu^f04554

(Yang et al., 2022)

NOT Suppressor of

Statement

Reference

Scer\GAL4^da.PU/Drp1^UAS.cUa is a non-suppressor of abnormal locomotor behavior phenotype of Pink1^B9

(Tsai et al., 2018)

Other

Statement

Reference

Drp1^UAS.cUa, Scer\GAL4^Mef2.PU, clu^f04554 has decreased size phenotype

(Yang et al., 2022)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Drp1^UAS.cUa, Scer\GAL4^GMR.PU is a non-enhancer of eye | adult stage phenotype of Hsap\FUS^{WT.UAS.RFP(Unk),Tag:HA}, Scer\GAL4^GMR.PU

(Deng et al., 2015)

Drp1^UAS.cUa, Scer\GAL4^GMR.PU is a non-enhancer of eye | adult stage phenotype of Hsap\FUS^{P525L.UAS.RFP(Unk),Tag:HA}, Scer\GAL4^GMR.PU

(Deng et al., 2015)

Suppressor of

Statement

Reference

Scer\GAL4^Mef2.PU/Drp1^UAS.cUa is a suppressor of mitochondrial crista | adult stage | decreased number phenotype of clu^f04554

(Yang et al., 2022)

Scer\GAL4^Mef2.PU/Drp1^UAS.cUa is a suppressor of adult somatic muscle cell of thorax phenotype of clu^f04554

(Yang et al., 2022)

Scer\GAL4^Mef2.PU/Drp1^UAS.cUa is a suppressor of mitochondrion | adult stage phenotype of clu^f04554

(Yang et al., 2022)

Scer\GAL4^Mef2.PU/Drp1^UAS.cUa is a suppressor of indirect flight muscle cell phenotype of clu^f04554

(Yang et al., 2022)

Drp1^UAS.cUa, Scer\GAL4^Mef2.247 is a suppressor | partially of flight muscle cell | adult stage phenotype of Cisd^UAS.cCa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

Drp1^UAS.cUa, Scer\GAL4^Mef2.247 is a suppressor | partially of mitochondrion | adult stage phenotype of Cisd^UAS.cCa, Scer\GAL4^Mef2.247

(Chen et al., 2020)

NOT Suppressor of

Statement

Reference

Scer\GAL4^da.PU/Drp1^UAS.cUa is a non-suppressor of mitochondrion | third instar larval stage phenotype of Pink1⁵

(Tsai et al., 2018)

Scer\GAL4^da.PU/Drp1^UAS.cUa is a non-suppressor of mitochondrial crista | third instar larval stage phenotype of Pink1⁵

(Tsai et al., 2018)

Scer\GAL4^da.PU/Drp1^UAS.cUa is a non-suppressor of embryonic/larval hypodermal muscle cell | third instar larval stage phenotype of Pink1⁵

(Tsai et al., 2018)

Other

Statement

Reference

Drp1^UAS.cUa, Scer\GAL4^Mef2.PU, clu^f04554 has mitochondrion phenotype

(Yang et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The adult eye phenotype (rough surface, pigmentation loss) characteristic for flies expressing either Hsap\FUS^{WT.Scer\UAS.T:Disc\RFP,T:Ivir\HA1} or Hsap\FUS^{P525L.Scer\UAS.T:Disc\RFP,T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU is not significantly modified by co-expression of Drp1^Scer\UAS.cUa, Drp1^{dsRNA.Scer\UAS.cUa}.

(Deng et al., 2015)

Complementation and Rescue Data

Rescues

Drp1^UAS.cUa rescues Drp1²/Drp1¹

(Chao et al., 2016)

Comments

The lethality of Drp1¹/Drp1² transheterozygotes is rescued by expression of Drp1^Scer\UAS.cUa under the control of Scer\GAL4^da.PU in the mutant background.

(Chao et al., 2016)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Drp1^Scer\UAS.cUa

Drp1^UAS.cUa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Unknown

Secondary FlyBase IDs

References (11)

Report Sections

Open Close