FB2024_03 , released June 25, 2024
Allele: Dmel\SLC22AlexAop.cGa
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General Information
Symbol
Dmel\SLC22AlexAop.cGa
Species
D. melanogaster
Name
Escherichia coli lexAop construct a of Gai
FlyBase ID
FBal0319344
Feature type
allele
Associated gene
Dmel\SLC22A
Associated Insertion(s)
Carried in Construct
P{LexAop-SLC22A.G}
Key Links
Transgenic product class
wild_type
(Gai et al., 2016)
Mutagen
    Nature of the Allele
    Transgenic product class
    wild_type
    (Gai et al., 2016)
    Mutagen
    Progenitor genotype
    Carried in construct
    P{LexAop-SLC22A.G}
    Cytology
    Description

    lexAop regulatory sequences drive expression of SLC22A.

    (Gai et al., 2016)
    Allele components
    Component
    Use(s)
    Regulatory region(s)
    lexAop
    Encoded product / tool
    SLC22A
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Ectopic expression of SLC22AEcol\lexAop.cGa in the mushroom body neurons using the Ecol\lexAGMR13F02 driver results in significant memory loss in adult flies.

        (Gai et al., 2016)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressed by
        Suppressor of
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Double mutant flies expressing AceKK101926 RNAi under the Scer\GAL4GH146 driver and SLC22AEcol\lexAop.cGa under the Ecol\lexAGMR13F02 driver show 3hr memory phenotype in a classical olfactory conditioning assay that is intermediate to either of the single mutants, the phenotypes being mutually suppressive.

        (Gai et al., 2016)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        SLC22AEcol\lexAop.cGa
        SLC22AlexAop.cGa
        Name Synonyms
        Escherichia coli lexAop construct a of Gai
        Secondary FlyBase IDs
          References (1)