FB2024_03 , released June 25, 2024
Allele: Dmel\mspsP18
Open Close
General Information
Symbol
Dmel\mspsP18
Species
D. melanogaster
Name
FlyBase ID
FBal0318773
Feature type
allele
Associated gene
Dmel\msps
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Third instar mspsP18/mspsP18 or mspsP18/mspsP larval central brains have a significant increase in neuroblast number. Extra neuroblasts are found in both type I (Scer\GAL4ase.neuro) and II (Scer\GAL4wor.PA and Scer\GAL80ase.PN) neuroblast lineages in mspsP18/mspsP18 clones. In mspsP18/mspsP18 mutant larval brains, most neuroblasts display random alignment of mitotic spindle, a small percentage show orthogonal division and apicobasal polarity is disrupted. mspsP18/mspsP mutants also show spindle misorientation in metaphase neuroblasts.

        (Chen et al., 2016)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        mspsP18 is rescued by mspsFL.UAS/Scer\GAL4insc.PU

        (Chen et al., 2016)
        Comments

        Expression of mspsFL.Scer\UAS driven by Scer\GAL4insc.PU rescues the phenotype of extra neuroblasts and spindle misorientation in metaphase neuroblasts in mspsP18/mspsP18 larval central brains.

        (Chen et al., 2016)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        mspsP18
        (Gujar et al., 2023, Tang et al., 2020, Chen et al., 2016)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)