A deletion resulting from the imprecise excision of the progenitor insertion which deletes sequences from -185 to +399 relative to the Arl2 ATG start codon.
Arl2Δ309/Arl2Δ309 clones have extra neuroblasts in both type I and II neuroblast lineages, compared to a single neuroblast in control clones (third instar larval central brain). Wild type interphase neuroblasts contain one major microtubule aster organized by the centrosome, whereas Arl2Δ309/Arl2Δ309 clones do not organize an aster and metaphase neuroblasts do not assemble mitotic spindle.
Co-expression of Arl2WT.Scer\UAS and COX7AScer\UAS.cCa driven by Scer\GAL4tub.PU rescues embryonic lethality in Arl2Δ309/Arl2Δ309 mutants.
Arl2Δ309 is partially rescued by Scer\GAL4insc.PU/Arl2WT.UAS
Expression of Arl2WT.Scer\UAS rescues the phenotype of extra neuroblasts in both type I and II neuroblast lineages seen in Arl2Δ309/Arl2Δ309 clones (Scer\GAL4insc.PU).