Compared to control clones in third instar larval brains, clones with expression of Hsap\NUMBScer\UAS.PTBS-PRRS have a cell cycle delay: there are a reduced number of neuroepithelial stem cells that have not differentiated into neurons on the lateral surface of the brain, and neuroblasts contain smaller numbers of neurons and ganglion mother cells; Hsap\NUMBScer\UAS.PTBS-PRRS clones containing only neurons on the medial surface near the central brain are found at a higher frequency than control clones.
Overexpression of Hsap\NUMBScer\UAS.PTBS-PRRS (or Hsap\NUMBScer\UAS.PTBL-PRRS) leads to dramatic wing margin balding (much more severe than Hsap\NUMBScer\UAS.PTBS-PRRL), when driven by Scer\GAL4bbg-C96, compared to controls; this represents a transformation toward neuronal fate.
Hsap\NUMBUAS.PTBS-PRRS is a suppressor of decreased cell number | somatic clone | third instar larval stage phenotype of NICN.UAS
Hsap\NUMBUAS.PTBS-PRRS/Scer\GAL4Tub.PU is a suppressor of abnormal neuroanatomy | somatic clone | third instar larval stage phenotype of numb15
Hsap\NUMBUAS.PTBS-PRRS/Scer\GAL4Tub.PU is a suppressor of decreased cell number | somatic clone | third instar larval stage phenotype of numb15
Hsap\NUMBUAS.PTBS-PRRS is a suppressor of neuron | somatic clone | third instar larval stage phenotype of NICN.UAS
Hsap\NUMBUAS.PTBS-PRRS/Scer\GAL4Tub.PU is a suppressor of neuron | somatic clone | third instar larval stage phenotype of numb15
Co-expression of Hsap\NUMBScer\UAS.PTBS-PRRS partially suppresses the inhibition of neuronal differentiation seen in clones with expression of NICN.Scer\UAS in third instar larval neuroblasts.
Expression of Hsap\NUMBScer\UAS.PTBS-PRRS driven by Scer\GAL4tub.PU suppresses neuronal differentiation defects seen in the outer optic anlage of numb15/numb15 clones in third instar larvae.