FB2024_03 , released June 25, 2024
Allele: Dmel\Diedel1
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General Information
Symbol
Dmel\Diedel1
Species
D. melanogaster
Name
FlyBase ID
FBal0318514
Feature type
allele
Associated gene
Dmel\Diedel
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Lamiable et al., 2016)
Mutagen
P-element activity
(Lamiable et al., 2016)
Progenitor genotype
P{XP}CG2310d06279
(Lamiable et al., 2016)
Caused by aberration
Df(3R)Diedel1
Cytology
Description

Deletion spanning the entire Diedel gene (nucleotides 3R:25318879..25320310 are deleted). The 5' coding portion of the neighbouring CG2310 gene is also removed. Generated by imprecise excision of P{XP}CG2310d06279.

(Lamiable et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:29,493,157..29,494,588 [+]
Comment:

A deletion generated by the imprecise excision of P{XP}CG2310d06279 is reported to map to 3R:25318879..25320310 in Release 5 coordinates. It removes all of Diedel as well as the 5' coding region of CG2310.

(Lamiable et al., 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Diedel1/Diedel1 flies show reduced viability (majority die during larval development) and a shorter lifespan compared to wild type. Diedel1/Diedel1 flies show reduced survival after immune challenge with a sublethal dose of Sindbis virus compared to wild type.

      Diedel1/Diedel1 flies are not sensitive (viability similar to wild type response) to the slowly replicating virus VSV, the fast replicating viruses Drosophila C virus, Cricket Paralysis virus or Flock House virus, the fungus Beauveria bassiana, the Gram-positive bacteria Enterococcus faecalis or the Gram-negative bacteria Enterobacter cloacae.

      Antibiotic treatment does not improve survival rates of Diedel1/Diedel1 flies.

      (Lamiable et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      NOT suppressed by
      Statement
      Reference

      Diedel1 has abnormal immune response | adult stage phenotype, non-suppressible by Dif1/Dif1

      (Lamiable et al., 2016)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Presence of keyc02831/keyc02831 partially suppresses the shorter lifespan in Diedel1/Diedel1 flies both in the absence of immune challenge and after Sindbis virus infection. Presence of imd1/imd1 (but not Dif1/Dif1) partially suppresses the shorter lifespan in Diedel1/Diedel1 flies after Sindbis virus infection.

      (Lamiable et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference

      Zzzz\SfAV-1a-dieScer\UAS.cLa expression driven by Scer\GAL4Act5C.PI partially suppresses the shorter lifespan seen in Diedel1/Diedel1 flies.

      (Lamiable et al., 2016)
      Complementation and Rescue Data
      Rescued by

      Diedel1 is rescued by DiedelUAS.cLa/Scer\GAL4Act5C.PI

      (Lamiable et al., 2016)
      Comments

      Expression of DiedelScer\UAS.cLa driven by Scer\GAL4Act5C.PI rescues the shorter lifespan seen in Diedel1/Diedel1 flies.

      (Lamiable et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Diedel1
      die1
      (Lamiable et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)