FlyBase Allele Report: Hsap\SLC2A3[UAS.cBa]

General Information

Symbol

Hsap\SLC2A3^UAS.cBa

Species

H. sapiens

Name

Saccharomyces cerevisiae UAS construct a of Besson

FlyBase ID

FBal0303665

Feature type

allele

Associated gene

Hsap\SLC2A3

Associated Insertion(s)

Carried in Construct

P{UAS-SLC2A3.B}

Key Links

Transgenic product class

wild_type

(Besson et al., 2015)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Besson et al., 2015)

Mutagen

in vitro construct

(Besson et al., 2015)

Progenitor genotype

Carried in construct

P{UAS-SLC2A3.B}

Cytology

Description

UASt regulatory sequences drive expression of Hsap\SLC2A3.

(Besson et al., 2015)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\SLC2A3

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Besson et al., 2015)

ameliorates Leigh disease

modeled by ND-23^KK102085

(Cabirol-Pol et al., 2018)

ameliorates amyotrophic lateral sclerosis type 16

modeled by Hsap\SIGMAR1^E102Q.UAS

(Couly et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Overexpression of Scer\GAL4^elav-C155>Hsap\SLC2A3^Scer\UAS.cBa alone has no effect on the photoreceptors.

(Besson et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Hsap\HTT^Q93.ex1.UAS, Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav-C155 has short lived phenotype, non-suppressible by Pfk^UAS.cTa, Scer\GAL4^elav-C155

(Besson et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, non-suppressible by Pfk^UAS.cTa, Scer\GAL4^elav-C155

(Besson et al., 2015)

Hsap\HTT^Q93.ex1.UAS, Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav-C155 has short lived phenotype, non-suppressible by G6pd^UAS.cLa, Scer\GAL4^elav-C155

(Besson et al., 2015)

Suppressor of

Statement

Reference

Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav.PU is a suppressor | partially of decreased cell number | adult stage | progressive phenotype of ND-23^KK102085, Scer\GAL4^elav.PU

(Cabirol-Pol et al., 2018)

Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav.PU is a suppressor | partially of short lived phenotype of ND-23^KK102085, Scer\GAL4^elav.PU

(Cabirol-Pol et al., 2018)

Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav-C155 is a suppressor of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Besson et al., 2015)

Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav-C155 is a suppressor of abnormal neuroanatomy phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Besson et al., 2015)

Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav-C155 is a suppressor of abnormal locomotor behavior phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Besson et al., 2015)

Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav-C155 is a suppressor of short lived phenotype of Pdha1^GD12103, Scer\GAL4^elav-C155

(Besson et al., 2015)

Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav-C155 is a suppressor of short lived phenotype of ND-23^KK102085, Scer\GAL4^elav-C155

(Besson et al., 2015)

NOT Suppressor of

Statement

Reference

Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav.PU is a non-suppressor of abnormal locomotor behavior | adult stage phenotype of ND-23^KK102085, Scer\GAL4^elav.PU

(Cabirol-Pol et al., 2018)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Hsap\HTT^Q93.ex1.UAS, Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav-C155 has eye photoreceptor cell phenotype, non-suppressible by Pfk^UAS.cTa, Scer\GAL4^elav-C155

(Besson et al., 2015)

Suppressor of

Statement

Reference

Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav.PU is a suppressor | partially of ommatidium | progressive phenotype of ND-23^KK102085, Scer\GAL4^elav.PU

(Cabirol-Pol et al., 2018)

Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav.PU is a suppressor | partially of photoreceptor neuron | progressive phenotype of ND-23^KK102085, Scer\GAL4^elav.PU

(Cabirol-Pol et al., 2018)

Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav-C155 is a suppressor of ommatidium phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Besson et al., 2015)

Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav-C155 is a suppressor of eye photoreceptor cell phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Besson et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The decreased lifespan, the decreased locomotor capacity and the ommatidium defects observed in adults expressing ND-23^KK102085 under the control of Scer\GAL4^elav.PU are partially or fully suppressed by the co-expression of Hsap\SLC2A3^UAS.cBa.

(Cabirol-Pol et al., 2018)

Co-expression of Hsap\SLC2A3^Scer\UAS.cBa extends the lifespan and ameliorates the climbing defects in flies expressing Scer\GAL4^elav-C155>Hsap\HTT^{Q93.ex1p.Scer\UAS}.

The disruption of ommatidial arrangements is markedly rescued in flies expressing Scer\GAL4^elav-C155>Hsap\HTT^{Q93.ex1p.Scer\UAS} when Hsap\SLC2A3^Scer\UAS.cBa is co-expressed.

Co-expression of Pfk^Scer\UAS.cTa has no additional effect on the survival or degeneration of photoreceptors in flies co-expressing Hsap\SLC2A3^Scer\UAS.cBa and Hsap\HTT^{Q93.ex1p.Scer\UAS} using Scer\GAL4^elav-C155.

Co-expression of Hsap\SLC2A3^Scer\UAS.cBa significantly suppresses the life-expectancy defects resulting from the expression of Scer\GAL4^elav-C155>l(1)G0334^GD12103.

Co-expression of Hsap\SLC2A3^Scer\UAS.cBa significantly suppresses the life-expectancy defects resulting from the expression of Scer\GAL4^elav-C155>ND-23^KK102085.

(Besson et al., 2015)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsap\SLC2A3^Scer\UAS.cBa

Hsap\SLC2A3^UAS.cBa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Besson

Secondary FlyBase IDs

References (4)

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